Muthu Krishnan, M (2021) Formulation and Evaluation of Novel Titanium Di Oxide in Situ Gel Sunscreen Lotion by using Lignin as Anti-Oxidant. Masters thesis, College of Pharmacy, Madurai Medical College, Madurai.
Full text not available from this repository.Abstract
The purpose of this research was to develop a novel titanium di oxide physical sunscreen lotion in situ gel system for the management of uv rays causing skin cancer with anti oxidant activity for preventing the early skin ageing. ❖ Ten formulations of titanium di oxide in situ gelling topical systems were prepared with thermo sensitive polymer Poloxamer-407 (10%) and poloxamer-188 (10%) in 2:1 & 1:2 ratio and other copolymers such as Carbopol 940 (0.5-1.5%), lignin (1%) by traditional “cold method”. ❖ The formulated in situ gelling topical system were characterized for appearance, colour, pH, gelation temperature, gelation time, viscosity study, sun protection factor, and anti- oxidant property. ❖ All the 10 formulations were clear and white in colour. ❖ The pH of all the formulations was in range from 5.0 to 5.8 and found to be satisfied. ❖ The prepared nano titanium di oxide in-situ gels showed sol-to-gel transformation. The gelation temperatures were in the range of 33.8 ºC to 37.9ºC and showed that the gelation times were in the range of 62 to 74 seconds. ❖ All the formulations showed the better viscosity behaviour at body temperature which was found to be in satisfactory range. ❖ Formulation F9 showed the optimum physiochemical behaviour such as gelation temperature, gelation time, viscosity, SPF, and anti-oxidant activity. ❖ Based on the physiochemical behaviours such as gelation temperature, gelation time, viscosity, SPF,anti-oxidant activity formulation F9 was considered as best formulation. ❖ The FTIR results proved that no interactions between the drug and polymers of in situ gelling system. ❖ The methodology adopted for the in situ gelling system is easy, convenient and cost effective. ❖ The prepared formulation produce a good transparent film on the skin compared to marketed product. ❖ This research demonstrated advantages of titanium di oxide in-situ gel and may be suitable for the management of uv rays causing skin problems compared to other sunscreen formulation which is to overcome the limitations of currently available formulation.
| Item Type: | Thesis (Masters) |
|---|---|
| Additional Information: | 261911303 |
| Uncontrolled Keywords: | Formulation, Evaluation, Novel Titanium Di Oxide, Situ Gel, Sunscreen Lotion, Lignin, Anti-Oxidant. |
| Subjects: | PHARMACY > Pharmaceutics |
| Depositing User: | Ramakrishnan J |
| Date Deposited: | 15 Aug 2022 06:27 |
| Last Modified: | 18 Aug 2022 02:33 |
| URI: | http://repository-tnmgrmu.ac.in/id/eprint/20775 |
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