Sreekala, M G (2021) Formulation and Evaluation of Teneligliptin Nanosuspension. Masters thesis, Cherraan’s College of Pharmacy, Coimbatore.
Full text not available from this repository.Abstract
In this present study, the drug Teneligliptin is selected based on literature review for the management of Type-2 Diabetes mellitus. ❖ The drug-excipient compatibility study results showed that there is no chemical change occur between the drug and the excipients and there was no functional group change observed. ❖ Teneligliptin is poorly water-soluble drug and it was fabricated as nanosuspension by using nano precipitation technique. In this method, nano size particle size of Teneligliptin was obtained by using different type of various proportions of stabilizers along with other ingredient at different stirring speed. ❖ The drug content was more for formulation 8(F8) ❖ For the prepared formulation (F1-F9) the particle size, polydisperseibility index and zeta potential were done. Among nine formulations, formulation 8(F8) results revealed that the values are desirable and stable. ❖ The scanning electron microspore study stated that the nano size particles were spherical in shape. ❖ Among all the formulations (F8) was optimized which showed maximum highest percentage of drug release at 24 hours. ❖ The cumulative percentage of drug release of formulation 8 (F8) increase with the optimum concentration of stabilizers and tween 80. ❖ The release rate of optimized formulation 8(F8) was fitted with various release kinetic studies and the selected formulation followed zero order kinetics. ❖ The results of stability study was confirmed that the prepared Teneligliptin nanosuspension is stable during the stability study. ❖ Nanosuspension drug delivery system is important novel drug delivery because of its submicron sized particles. It has potential merits in enhance the bioavailability and improve the patient compliance. This nanosuspension technology is used for dose titration therapy in type-2 diabetes mellitus. The reduced size particles as nanosuspension can be applicable to BCS Class Ⅱ drugs and hence increase the solubility thus, increase the absorption of the drug in GIT. This nanosuspension technique is commercially feasible and cost effective.
| Item Type: | Thesis (Masters) |
|---|---|
| Additional Information: | 261911006 |
| Uncontrolled Keywords: | Formulation, Evaluation, Teneligliptin Nanosuspension. |
| Subjects: | PHARMACY > Pharmaceutics |
| Depositing User: | Ramakrishnan J |
| Date Deposited: | 15 Aug 2022 06:25 |
| Last Modified: | 18 Aug 2022 02:15 |
| URI: | http://repository-tnmgrmu.ac.in/id/eprint/20772 |
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