Sundaramoorthy, S (2021) Formulation and Evaluation of Nevirapine Extended Release Tablets. Masters thesis, Annai J.K.K. Sampoorani Ammal College of Pharmacy, Komarapalayam.
Full text not available from this repository.Abstract
Nevirapine is a non-nucleoside reverse transcriptase inhibitor (NNRTI) drug which is used in the treatment human immunodeficiency virus type 1 (HIV-1) infections. In this study Nevirapine Extended release tablets were prepared by using hydrophobic polymers. Thirteen formulations of extended release tablets of Nevirapine were developed by using Lactose Monohydrate and Micro crystalline cellulose as diluent and Magnesium stearate as lubricant in different proportions and varying grades of Eudragit, Ethyl Cellulose and povidone in different proportions. The formulation F12 was found to be best of all the formulations showing drug release matching the innovator product. The formulation F12 was evaluated for all the quality control tests. Stability study is carried out for 3 months at 25°C; 60% RH: and 40°C; 75%RH, according to ICH guidelines. The tablets were tested for drug release and percentage label claim during the stability period and confirmed that the results were found within the limits. The identified formula shall be utilized for the formulation development and other studies for successful launching of the product.
| Item Type: | Thesis (Masters) |
|---|---|
| Additional Information: | 261910811 |
| Uncontrolled Keywords: | Formulation, Evaluation, Nevirapine Extended Release Tablets. |
| Subjects: | PHARMACY > Pharmaceutics |
| Depositing User: | Ramakrishnan J |
| Date Deposited: | 12 Aug 2022 11:21 |
| Last Modified: | 12 Aug 2022 11:21 |
| URI: | http://repository-tnmgrmu.ac.in/id/eprint/20757 |
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