Munirathinam, M (2022) Effect of Natural and Synthetic Superdisintegrants in the Formulation of Diltiazem Hydrochloride Orodispersible Tablets: A Comparative study. Masters thesis, J.K.K.Nattraja College of Pharmacy, Kumarapalayam.
Full text not available from this repository.Abstract
The oro dispersible Tablets (ODT’s) of Diltiazem hydrochloride were prepared by Direct compression method using various super disintegrants. Formulation F8 containing 10%w/v concentration of Cros Povidone with appropriate amount of other excipients were considered to be the optimized formulation with the desired drug release. The oro dispersible Tablet formulation of Diltiazem hydrochloride provides instant relief for migraine sufferers and helps them to resume their normal function as soon as possible. All formulation were found to have homogenic drug distribution with excellent content uniformity. F8 batch contains 10% CP was optimized. Comparative drug release study revealed that the formulated Oro dispersible tablets [ODT’s] release drug more rapidly than the marketed sample. The results of stability studies revealed that the formulation F8 showed no significant variations in all the parameters and was stable for a period of 3 months. The optimized formulation F8 was found to follow First order kinetics, which was revealed by the linearity shown from the plot of logarithm of drug remaining to be released versus time. In future, the developed formulation F8 can be subjected to Bioequivalence study and suitability to the market can be decided based on that. Orodispersible tablets of Diltiazem hydrochloride tabltes prepared by direct compression technique containing synthetic superdisintegrants crospovidone (5%) was found to be better disintegration property because of its combination effect of swelling and wicking and showed best in-vitro dissolution profile than the formulations containing natural superdisintegrants (hibiscus leaves dried mucilage and plantago ovata seed mucilage). Hence, it can be concluded that using a crospovidone can be used as a first choice fof superdisintegrant for the formation of orodispersible tablets.
| Item Type: | Thesis (Masters) |
|---|---|
| Additional Information: | 291910260 |
| Uncontrolled Keywords: | Natural, Synthetic Superdisintegrants, Formulation, Diltiazem Hydrochloride Orodispersible Tablets, Comparative study. |
| Subjects: | PHARMACY > Pharmaceutics |
| Depositing User: | Ramakrishnan J |
| Date Deposited: | 12 Aug 2022 07:52 |
| Last Modified: | 12 Aug 2022 07:52 |
| URI: | http://repository-tnmgrmu.ac.in/id/eprint/20731 |
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