Rashmi, S (2021) Formulation and Evaluation of Gastroretentive Floating Microspheres of Levofloxacin Hemihydrate for the Treatment of H. Pylori Infection. Masters thesis, J.K.K.Nattraja College of Pharmacy, Kumarapalayam.
Full text not available from this repository.Abstract
Floating microspheres of Levofloxacin were prepared using Eudtagit RSPO and HPMC K15M. The nature of polymer influenced the physical characteristics as well as floating behaviour of the microspheres. In vitro buoyancy study confirmed the excellent floating properties of microspheres. Floating microspheres of Levofloxacin hemihydrate were successfully prepared loaded Eudragit RSPO/HPMC K15M microspheres formulations could be developed that effectively sustain the drug release for a desired period by varying the ratio of Eudragit RSPO/HPMC K15M. Solvent Ratio and stirring rate. In vitro data obtained for floating microspheres of Levofloxacin hemihydrate showed excellent floatability, good buoyancy, and prolonged drug release. According to the results of FTIR and DSC no drug interaction was occurred with polymer. Floating microspheres of different size and drug content could be obtained by varying the formulation variables. Diffusion was found to be the main release mechanism. Thus, the prepared floating microspheres may prove to be potential candidates for multipleunit delivery devices adaptable to any intragastric condition. Thus, the stomach specific floating microspheres drug delivery of Levofloxacin hemihydrate can be a promising drug delivery system for the treatment of H. pylori infection in peptic ulcer in desired therapeutic concentration at lower dose with reduced adverse effect. For further confirmation, it requires the in vivo study in animals or healthy volunteers.
| Item Type: | Thesis (Masters) |
|---|---|
| Additional Information: | 261910263 |
| Uncontrolled Keywords: | Formulation, Evaluation, Gastroretentive Floating Microspheres, Levofloxacin Hemihydrate, Treatment, H.Pylori Infection. |
| Subjects: | PHARMACY > Pharmaceutics |
| Depositing User: | Ramakrishnan J |
| Date Deposited: | 12 Aug 2022 07:47 |
| Last Modified: | 12 Aug 2022 07:47 |
| URI: | http://repository-tnmgrmu.ac.in/id/eprint/20730 |
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