Mohamed Izzeldein Elbashir Mohamed, (2021) Formulation and In-Vitro Characterization of Favipiravir Floating Tablets using HPMC K15 M and Carbopol-940P as Polymers. Masters thesis, J.K.K.Nattraja College of Pharmacy, Kumarapalayam.
Full text not available from this repository.Abstract
Oral drug administration is by far the most preferable route for taking medications. However the therapeutic window of many drugs is limited by their short circulating half-life and absorption via a defined segment of the GIT. Such pharmacokinetic limitations may lead in many cases to frequent dosing of these medications to achieve the required therapeutic effect and hence poor patient compliance. Favipiravir an oral anti-viral agent majorly absorbed from upper GI tract. It is a rapidly absorbed drug having faster elimination rate, it was a good candidate for floating drug delivery system. Physical mixtures were evaluated for bulk density, tapped density, Carr’s index and Hausner ratio. Characterization of drug and polymer mixture were done by performing FTIR and it was concluded that there was no interaction between the drug and polymer as the principle peaks of the drug were found unaltered in the IR spectra of drug polymer physical mixture. In the present study an attempt was made to prepare the Floating tablets of Favipiravir were prepared by Effervescent floating technique. The formulations were prepared by polymers HPMC K4M and carbopol 940 used, and incorporating NaHCo3 into tablets resulting in floating of tablet in simulated gastric fluid. Tablets were formulated with different ratios of HPMC K4M and carbopol 940 individually and combination of polymers. The formulations were evaluated for physical tests, buoyancy lag time and dissolution. On the performance with respect to buoyancy lag time, floating time and the release characteristics, the formula (F9) was selected as the best formula as it showed a buoyancy time 55 seconds, floatation time of 24 hours, and Cumulative % drug release of 96.65%. This Formulation (F9) showed a sustained release rate throughout its release period. And the selected formulation (F9) was compared with the marketed formulation. Selected formulation GFT9 had released the 96.65% of drug.
| Item Type: | Thesis (Masters) |
|---|---|
| Additional Information: | 261910259 |
| Uncontrolled Keywords: | Formulation, In-Vitro Characterization, Favipiravir Floating Tablets, HPMC K15 M, Carbopol-940P, Polymers. |
| Subjects: | PHARMACY > Pharmaceutics |
| Depositing User: | Ramakrishnan J |
| Date Deposited: | 12 Aug 2022 07:17 |
| Last Modified: | 12 Aug 2022 07:17 |
| URI: | http://repository-tnmgrmu.ac.in/id/eprint/20728 |
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