Formulation Development and Invitro Evaluation of Clarithromycin Floating Sustained Release Tablets

Magesh, V (2021) Formulation Development and Invitro Evaluation of Clarithromycin Floating Sustained Release Tablets. Masters thesis, J.K.K.Nattraja College of Pharmacy, Kumarapalayam.

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Abstract

From the current research work of clarithromycin floating tablet formulation the following conclusion drawn:- • Preformulation studies of drug and excipients (Drug + Polymer + excipient blend) were performed. From the FT-IR spectra, the interference was verified and found that Clarithromycin did not interfere with the excipients used in the formulations. • Twelve batches of clarithromycin floating tablet formulation were formulated. • The formulated tablets of CF-01 to CF-12 were evaluated for parameters such as thickness, hardness, friability, weight variation, in-vitro drug release studies, swelling index, floating time and drug release kinetic studies. • Based on the results obtained from CF-01 to CF-12, formulation CF-12 having Carbopol-940 clarithromycin floating tablet was identified as ideal and better formulation among all formulations developed. • In-vitro release of optimized formulation of Clarithromycin floating tablets of CF-12 was found to be 92.18% drug release for 12 hrs. extended period. • CF-12 formulation shows the more floating time duration about 12 hrs. 53 min and Buoyant lag time of 161 sec. Hence, It is concluded the formulation containing carbopol 940 clarithromycin floating tablet (CF-12) exhibits better controlled release rate in comparatively to other formulations. Prepared formulation gave good results for various physico-chemical parameters evaluation. Optimized formulations from each polymer (CF-04)-HPMC K100M, (CF-08)- Ethyl Cellulose and (CF-12) Carbopol 940 follows Higuchi model release kinetics.

Item Type: Thesis (Masters)
Additional Information: 261910258
Uncontrolled Keywords: Formulation, Development, Invitro Evaluation, Clarithromycin Floating Sustained Release Tablets.
Subjects: PHARMACY > Pharmaceutics
Depositing User: Ramakrishnan J
Date Deposited: 12 Aug 2022 07:08
Last Modified: 12 Aug 2022 07:08
URI: http://repository-tnmgrmu.ac.in/id/eprint/20726

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