Abdul Rahman, M (2021) Formulation and Evaluation of Transdermal Patches of Nitroglycerin and Salicyclic Acid. Masters thesis, K.M.College of Pharmacy, Madurai.
Full text not available from this repository.Abstract
Partition coefficient of the drugs selected for the present study was favourable for designing the transdermal drug delivery system. • There was no polymer-drug interaction in all the optimized formulations was further confirmed by FTIR. • Similarly the optimized formulation of Nitroglycerin was the patch containing 1% EC, 2% HPMC and 1% PVP with released the drug to 97.86% and upto the expected time of 12hr. • The release in all the above optimized formulations of Nitroglycerin was influenced by the presence of HPMC. • The transdermal administration of Nitroglycerin is a possible solution to overcome these problems for long-term treatment of angina. • Sometimes patches are placed the particular area and then removed by the certain time there formed some of the bacterial infection. So they are rectified with the help of some antibacterial agent and adding like salicylic acid. • The release observed in all the optimized formulations was diffusion mediated non fickian type which was confirmed by the slope values of Higuchi’s and Peppa’s plots. • Thus, the optimized formulations have achieved the objectives of sustained release or reduced frequency of administration, avoidance of first pass effect and improved the patient compliance. • As an extension of this work, pharmacokinetic studies, in-vivo studies on higher animals and controlled clinical studies on human beings can be carried out in future.
| Item Type: | Thesis (Masters) |
|---|---|
| Additional Information: | 261910101 |
| Uncontrolled Keywords: | Formulation, Evaluation, Transdermal Patches, Nitroglycerin, Salicyclic Acid. |
| Subjects: | PHARMACY > Pharmaceutics |
| Depositing User: | Ramakrishnan J |
| Date Deposited: | 12 Aug 2022 05:09 |
| Last Modified: | 12 Aug 2022 08:11 |
| URI: | http://repository-tnmgrmu.ac.in/id/eprint/20713 |
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