Bone Marrow Morphology in Multiple Myeloma.

Yegumuthu, K (2012) Bone Marrow Morphology in Multiple Myeloma. Masters thesis, PSG Institute of Medical Sciences & Research, Coimbatore.


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Multiple myeloma is a clonal plasma cell disorder that varies widely in its clinical course ranging from relatively indolent forms to frankly aggressive neoplasia [1]. The clinical manifestations of this disorder result from the proliferation and accumulation of these neoplastic cells and, the effect of marrow replacement by them. The pathologic manifestations are due to over production of certain proteins and constituent polypeptide chains. Bone marrow examination continues to be the cornerstone for establishing a diagnosis in association with other clinical and laboratory parameters [2]. Several clinical, laboratory and morphological variables help us in determining the prognosis of the disease. The first histological classification and staging of myeloma was put forth by Bartl et al in 1987[2]. Multiple myeloma has been classified into 6 histological types: · Marschalko type · Small cell type · Cleaved type · Polymorphous type · Asynchronous type Stifter S, Babarovic E, Valkovic T, Seilibekafigo I, Stemberger C,Nacinovic A, et al. Combined evaluation of bone marrow aspirate and biopsy is superior in the prognosis of multiple myeloma.Diagn Pathol.2010.5 : 30 54. Sailer M, Vycoupil K F, Peest D, Coldeway R, Deicher H and Georgii A. Prognostic relevance of a histologic classification system applied in bone marrow biopsies from patients in multiple myeloma.A histopathological evaluation of biopsies from 153 patients.Eur j Haematol, 1995. 54;137- 46 55. G Merlini, J G Waldenstrom and S D Jayakar. A new improved clinical staging system for multiple myeloma based on analysis of 123 patients. Blood, 1980. 55; 1011 – 19 56. Bartl R, Frisch B, Burkhardt R, Moghadam A F, Mahl G,Gierster P et al. Bone marrow histology in myeloma: its importance in diagnosis

Item Type: Thesis (Masters)
Uncontrolled Keywords: Bone Marrow Morphology; Multiple Myeloma.
Subjects: MEDICAL > Pathology
Depositing User: Subramani R
Date Deposited: 21 Jun 2017 11:58
Last Modified: 22 Jun 2017 10:40

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