Tumor Neoangiogenesis in Locally Advanced Breast Cancer: A Clinicopathological study.

Basawantrao, Malipatil (2014) Tumor Neoangiogenesis in Locally Advanced Breast Cancer: A Clinicopathological study. Masters thesis, Cancer Institute (WIA), Chennai.


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Introduction: India with a population of 1.2 billion (2011 census) is the most populous democratic Country in the world and will surpass China by 2025 (1). Though the incidence of Communicable diseases is still challenging the burden of non-communicable diseases Like cancer is increasing in India. The incidence of breast cancer has increased over the decades around the World. It was estimated that there were 1.5 million cases of breast cancers in 1999 a 82% increase from year 1990 (2). Breast cancer is the most common cause of cancer Death among women only next to lung cancer (3). The greatest increase in incidence has been in Asian women which peaks in The forties in contrast to Western women where it peaks in the sixties (4,5). Fifty Percent of Indian women are premenopausal (5) and has been projected that majority Of breast cancer burden will be in Asian women. The incidence of breast cancer in India until about 10 years ago was 10 per 100,000 women which has increased currently to 23 per 100,000 (6). There were 115,000 patients with breast cancer and 53,000 deaths (3) in 2008. The rate of Increase in incidence of breast cancer is 0.5 – 2% per annum and more so in younger Age groups (<45 years) (7). As the median age of the population of women in India is Young, the proportion and median age of patients with breast cancer is also less than 50. For example, the median age of patients with breast cancer in 6 hospital-based Cancer registries ranged from 44.2 years in Dibrugarh, 46.8 years in Delhi, 47 years In Jaipur, to 49.6 years in Bangalore and Chennai. The average age reported from Other parts of country varies from 50 – 53 years (National Cancer Registry Programme, 2001) with significant population younger than 35 years (11% at TMH, Mumbai (8), and 26% at SGPGIMS, Lucknow (5)). The awareness of breast cancer is good in the West and in addition, better Screening and health care facilities have improved the survival of patients to >80% in North America and Europe compared to 60% and 40% in middle-income and lowincome Countries respectively (9). There is even variation in presentation with more Women presenting in early stage in the West compared to those with advanced Disease in the developing world (10). 69 percent of the patients presenting to our hospital have locally advanced Breast cancer (LABC) (11). Understanding the pathogenesis of the disease will allow The development of targeted drugs (including anti-angiogenic therapy) other than Chemotherapy to tackle this huge burden.

Item Type: Thesis (Masters)
Uncontrolled Keywords: Tumor Neoangiogenesis ; Locally Advanced Breast Cancer ; Clinico pathological study.
Subjects: MEDICAL > Medical Oncology
Depositing User: Subramani R
Date Deposited: 19 Aug 2017 03:32
Last Modified: 19 Aug 2017 03:32
URI: http://repository-tnmgrmu.ac.in/id/eprint/2029

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