Sarathkumar, K (2023) Serum Uric Acid Levels and End Organ Damage in Essential Hypertension. Masters thesis, Kilpauk Medical College, Chennai.
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Abstract
INTRODUCTION: Serum uric acid plays a role in the development of cardiovascular morbidity in the general population and in patients with hypertension. In addition uric acid has proved to an excellent marker for tissue ischemia and endothelial dysfunction. The presence of subclinical hypertensive organ damage signals a condition of increased risk for cardiovascular and renal morbidity and mortality. Thus the search for left ventricular hypertrophy (LVH), carotid atherosclerosis and microalbuminuria which likely reflect both the severity of blood pressure load and other non hemodynamics risk factors is currenty recommemded as a part of global risk assessment. AIM OF THE STUDY: To evaluate the correlation between serum uric acid levels and the presence of end organ damage in essential hypertension. OBJECTIVES: To identify the patients with essential hypertension and to measure serum uric acid levels 1. To measure albuminuria, 2. To assess LV dysfunction by ECHO, 3. To examine the fundus for retinopath. MATERIALS AND METHODS: STUDY DESIGN: Observational Cross Sectional study. STUDY POPULATION: Patients with essential hypertension admitted in department of general medicine of Govt. Kilpauk Medical College. • The current study reports a high prevalence of hypertension in the age group of 51-60 years of age (30.0%), followed by 61-70 years of age (26%), and the age range of 41-50 years (24%). • A high male predominance was reported in the current study comprising 76 males (76%) and 24 females. • Most of the patients were reported to be in the normal range of BMI, comprising 59 individuals (59%) • A history of diabetes was reported in 19 patients (19%) from the overall study. • A total of 14 patients was diagnosed with left ventricular hypertrophy, whereas 86 patients did not have any significant finding. • Thirty-six patients were reported to be diagnosed with coronary artery disease comprising 36% of the participants from the study. • Albuminuria was seen in 44 patients (44%), whereas 56 patients were not diagnosed with such a condition. • Retinopathy was reported in 44 patients, out of which stage I retinopathy was reported in 26 patients (26%) and stage II retinopathy was seen in 18 patients (18%). • Elevated serum uric acid levels were observed in 10 patients (10%), and eight (8%) reported low or serum uric acid levels. • Elevated levels of serum uric acid were seen in 10 patients with essential hypertension, out of which the age group of >71 was seen with 3 cases of high serum uric acid levels. • high levels of serum uric acid were seen in males comprising nine individuals, whereas low levels were seen higher in males (5 individuals) and females (3 individuals). • There is no significant correlation between albuminuria and retinopathy with serum uric acid levels. CONCLUSION: • The current study reports that serum uric acid levels can be seen as an independent factor for the development of hypertension and, without adequate treatment, can lead to target organ damage. The prevalence of hyperuricemia was reported in 10 individuals (10%), and hypouricemia was seen in 8 individuals (8%) from the total study. • The study did not report any significant correlation of serum uric acid levels with age, gender, BMI, social habits, or comorbid condition. However, based on the literature and clinical requirements, hyperuricemia can be seen in patients with essential hypertension.
| Item Type: | Thesis (Masters) |
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| Additional Information: | Reg.No:200120102021 |
| Uncontrolled Keywords: | Serum Uric Acid Levels, End Organ Damage, Essential Hypertension. |
| Subjects: | MEDICAL > General Medicine > MEDICAL > General Medicine |
| Depositing User: | Thavamani K |
| Date Deposited: | 26 May 2022 05:48 |
| Last Modified: | 22 Mar 2024 16:38 |
| URI: | http://repository-tnmgrmu.ac.in/id/eprint/20213 |
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