Sanda Kavitha, (2023) Association of Carotid Intimal Thickness with Hematological Indices in Predicting Macro-Vascular Complications in Type 2 Diabetes Mellitus. Masters thesis, Madras Medical College, Chennai.
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Abstract
BACKGROUND AND OBJECTIVES: Diabetes mellitus is a global burden in this present era, leading to morbidity physically and economically. The prevalence of dm was 2.8% in 2000 now increased to 4.4% in 2030.Type 2 diabetes mellitus is a chronic inflammatory state with tendency to form thrombosis and leading to vascular diseases, recently inexpensive novel markers easily accessible hematological indices are being evaluated. Measuring the carotid intima media thickness using carotid Doppler has been appeared as a non- invasive and quantitative modality to detect these early macro-vascular changes to assess hematological parameters in type 2 diabetes mellitus, and to correlate with carotid intimal thickness in predicting macro-vascular complications. METHODS: This study was conducted in Rajiv Gandhi Government General Hospital from June2022 to November 2022. A total 100 case were studied. The Hematological indices, HBA1c and CIMT parameter were included and assessed. Data was entered in MS excel sheet and analyzed using SPSS version 21.0. Chi square test and Fisher’ s exact test was used for finding association. RESULTS: Among 100 participants, both male and females are equally represented with 50 each and both are comparable with respect to age. (p>0.05). The age group of the study participants varies from 31 to 70 years. Maximum number of study participants were at 41 to 50 years age group. Mean age of the study participants was 45.38 ± 7.60 years. Among 100 participants, both male and females are equally represented with 50 each and both are comparable with respect to age. (p>0.05). HAEMOTOLOGICAL INDICES; 62% had neutrophil lymphocyte ratio of >2. All those with >2 (100%) NLR was found to have increased carotid intimal thickness of >2 compared to 2.6% of those with NLR <2. (p<0.001). Among those with RDW >15, 88.7% showed carotid intimal thickness of >0.8 compared to 21.1% in those with RDW 11-15.The Mean Platelet volume was found to be >12 in 58 diabetes mellitus patients in the study. Among them 91.4% had increased carotid intimal thickness of >0.8. However, among those with Mean platelet volume between 7 to 12, the carotid intimal thickness was found to be increased (>0.8) in only 23.8%. CONCLUSION: In this study showed among diabetics with poor glycemic control have significant increase in CIMT. and there has been correlation between NLR, RDW, MPV in association with CIMT.
| Item Type: | Thesis (Masters) |
|---|---|
| Additional Information: | 200120100528 |
| Uncontrolled Keywords: | Association of Carotid Intimal Thickness with Hematological Indices in Predicting Macro-Vascular Complications in Type 2 Diabetes Mellitus |
| Subjects: | MEDICAL > General Medicine > MEDICAL > General Medicine |
| Depositing User: | Thavamani K |
| Date Deposited: | 26 May 2022 05:48 |
| Last Modified: | 17 Mar 2024 15:52 |
| URI: | http://repository-tnmgrmu.ac.in/id/eprint/20209 |
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