Early Onset Schizophrenia: A Comparative study of Clinical Features and Premorbid Function with Adult Onset Group.

Deepa, V (2007) Early Onset Schizophrenia: A Comparative study of Clinical Features and Premorbid Function with Adult Onset Group. Masters thesis, Madras Medical College, Chennai.


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INTRODUCTION: Schizophrenia is a devastating chronic disorder that typically presents in early adult life. Clinicians are circumspect about making this ominous diagnosis in children and adolescents. The relative rarity of the disorder in this age group together with atypical presentations complicate the picture further. Over the past decade research activity in children and adolescents has been sparked by several factors .Awareness of the greater clinical severity of Schizophrenia in childhood and adolescence and the possibility of greater etiological liability have encouraged researchers to investigate genetic and neurobiological correlates in early onset cases(Jacobsen and Rapoport,1998) The emergence of neuro developmental formulation of Schizophrenia (Weinberger, 1987) and the perspective of developmental psychopathology have focused attention on early developmental processes and the premorbid childhood course of Schizophrenia from birth to onset. The disorder is associated with deficits in cognition, affect and social functioning. Onset of illness rarely occurs before 13years, but then increases steadily during adolescence. Accurate diagnosis and treatment requires familiarity with clinical presentation, phenomenology and course of the disorder. Adolescent schizophrenia is considered as a more severe variant of adult schizophrenia. Early diagnosis and treatment can prevent devastating consequences. Additionally, the study of early onset variants of the disorder often enables the examination of a more genetically homogenous and less environmentally influenced disease condition.As such, understanding early onset schizophrenia may possibly provide useful information about etiology and course of adult onset schizophrenia. While ongoing research continues our understanding of biological and environmental factors associated with and contributing to the disorder, the rarity of the condition has resulted in only modest gains in understanding. Factors associated with early onset schizophrenia such as basic demographics, phenomenology, course and outcome still remain as areas of mystery. Research in adolescent schizophrenia has needed to address the key questions of 1. continuity and discontinuity with adult schizophrenia. 2. The clinical and aetiological significance of atypically early onset of schizophrenia in adolescence. In several studies the terms childhood onset, adolescent-onset and early-onset were used interchangeably. In response to lack of precise definitions, Werry(1991) proposed the use of term Early onset (EO) to describe adolescent onset schizophrenia between ages 13 to 17(both included).According to practice parameters issued by American Academy of Child and Adolescent Psychiatry, early onset schizophrenia(EOS)(adolescent schizophrenia) is defined as onset before 18 yrs age, with very early onset (VEOS) developing before 13 years.

Item Type: Thesis (Masters)
Uncontrolled Keywords: Schizophrenia ; Clinical Features ; Premorbid Function ; Adult Onset Group.
Subjects: MEDICAL > Psychiatry
Depositing User: Subramani R
Date Deposited: 19 Aug 2017 03:28
Last Modified: 19 Aug 2017 03:28
URI: http://repository-tnmgrmu.ac.in/id/eprint/2020

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