Immunohistochemical Analysis of expression of CD 15 in various Thyroid Neoplasms.

Rajeshwari, K M (2011) Immunohistochemical Analysis of expression of CD 15 in various Thyroid Neoplasms. Masters thesis, PSG Institute of Medical Sciences & Research, Coimbatore.

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Abstract

The thyroid gland is one of the most responsive organs in the body and is a large store of hormones. The gland responds to many stimuli and is in a constant state of adaptation. Thyroid hormones regulate the body's metabolism too. They have a bearing on the heart rate, cholesterol level, body weight, energy level, muscle strength, skin condition, menstrual regularity, memory function and many other conditions [1]. Diseases of thyroid gland especially mass lesions are easily accessible and amenable to surgical treatment and cure. Thyroid malignancies represent the most common malignancies of the endocrine system. With environmental and genetic factors playing a role, there is an increase in incidence of these malignancies. Due to the dependence of thyroid on environmental iodine, it is particularly vulnerable to the genotoxic effects (DNA damage) of radioactive iodine and to the non genotoxic effects (TSH stimulation) resulting from iodine deficiency. The role of iodine is mediated through the growth stimulatory effects of high TSH levels CD 15 immunohistochemical marker is being studied as a prognostic marker for thyroid malignancies. Though only 24% of the thyroid neoplasms showed expression of CD15 in our study group, it was found to be positive in all those malignancies presenting at a higher clinical stage and also with poor prognostic indicators such as blood vessel invasion. Our study also brought out a considerable percentage of expression of CD15 in two cases of follicular adenoma, where a focus showed typical nuclear features of papillary carcinoma explaining the possibility of missing a papillary focus in an otherwise follicular adenoma. Though from our study, it is proved that CD15 can be used for prognostication and diagnosis of thyroid malignancies; a larger prospective study recruiting more number of cases is essential to prove the utility of CD 15 expression as a prognostic and diagnostic marker.

Item Type: Thesis (Masters)
Uncontrolled Keywords: Immunohistochemical analysis; expression of CD 15; Thyroid Neoplasms
Subjects: MEDICAL > Pathology
Depositing User: Subramani R
Date Deposited: 21 Jun 2017 11:31
Last Modified: 22 Jun 2017 05:54
URI: http://repository-tnmgrmu.ac.in/id/eprint/202

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