Annal Thamaraiselvi, J (2019) Development and Evaluationof Anti Diabetic Activity of Cassia Auriculata Linn Nanoparticles. Masters thesis, K. M. College of Pharmacy, Madurai.
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Abstract
Medicinal plant species constitute important alternatives to conventional medicine in a large number of developing countries, especially within poor communities that inhabit rural areas and lack access to health services. Cassia auriculata.L flowers might be a potential alternative agent for antidiabetic activity. Hence it is anticipated that Cassia auriculata flower would be a useful pharmaceutical material to treat diseases. This investigation may focus research field to develop clinical studies which might be of great scientific contribution for the society. The importance of medicinal plants in traditional health care practices clues to new areas of research and in biodiversity conservation. The two invitro antidiabetic methods have been performed and found to be α-amylase inhibition and glucose uptake of different extracts. To identify the active constituents. Further studies are required to purify the active principle and study the molecular mechanism of the exact pathway. This information’s will be useful for the development of alternative method rather than insulin and hypoglycemic agents for the treatment of diabetes mellitus. From the results of the present experiments it may be concluded that formulation F3 showing formulation of Nanoparticle size, high percentage of entrapment and desired sustained release of Nanoparticle. Hence F3 formulation was optimized one. The optimized formulation F3 was found to follow zero order release pattern which was revealed by the linearity shown from the plot of time versus concentration. Nanoparticle formation were stable for 4 weeks at 40C and affirm the drug leakage – increased the higher temperature. Comparative study of Nanoparticle formulation with the marketed. The Nanoparticle formulation revealed that anti diabetic activity was released from the Nanoparticle formulation in a sustained manner for 24 Hours. Thus the aim of the project was achieved by optimizing the formulation Parameters.
| Item Type: | Thesis (Masters) |
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| Additional Information: | 261710101 |
| Uncontrolled Keywords: | Anti Diabetic Activity, Cassia Auriculata Linn Nanoparticles |
| Subjects: | PHARMACY > Pharmaceutics |
| Depositing User: | Ramakrishnan J |
| Date Deposited: | 23 May 2022 09:39 |
| Last Modified: | 23 May 2022 09:39 |
| URI: | http://repository-tnmgrmu.ac.in/id/eprint/20177 |
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