Vishnu Prakash, M (2019) Formulation and Evaluation of Chitosan Based Hydrogel Matrix of Licorice for Targeting Helicobacter Pylori. Masters thesis, C.L.Baid Metha College of Pharmacy, Chennai.
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Abstract
In present investigation an attempt has been made to formulate and evaluate chitosan based hydrogel of matrix of Licorice for targeting Helicobacter pylori. Licorice was evaluated for its physical characteristics, analytical profiles and drug polymer compatibility study. The prepared Hydrogel granules were evaluated for pre formulation characteristics like Angle of repose, Bulk density, Tapped density and Carr’s index. The results obtained were found to be satisfactory and within the specified limits. A Stomach retentive licorice loaded chitosan hydrogel was prepared successfully by chemical crosslinking method. Glutaraldehyde was used as chemical crosslinking agent. After compression parameters like Thickness, Hardness, Weight variation, Friability, content uniformity and In-Vitro release studies were evaluated. Mucoadhesive study showed that, licorice loaded hydrogel have good mucoadhesion property and retained in gastric environment tof stomach for prolonged period of time. The results of In-vitro studies showed that by chitosan concentration the extent of swelling and rate of drug release can be modulated. In the present study the effect of concentration of polymer are studied through In-Vitro drug release. It shows that increase in concentration of polymer leads to the controlled drug release from hydrophilic chitosan hydrogelfor12 hrs, which means release rate from hydrophilic chitosan hydrogel depends on type and concentration of polymer used in the formulation. Hydrogel formulation (F5), containing chitosan and Crosslinking agent of Glutaraldehyde is probably showing release upto 96.2±0.65% within 12 hrs. The hydrogel prepared maintain drug concentration in stomach for prolonged period of time, can be used as a drug delivery system for treatment of H. pylori infection and in management of peptic ulcer. According to stability study it was found that there was no significant change in average weight, drug content and in vitro dissolution of optimized formulation (F5). This can be expected to reduced the frequency of administration and decrease the dose dependent side effects. The efficacy and safety of Licorice hydrogel dosage form are expected to offer optimum therapeutic efficacy and improved patient compliance.
| Item Type: | Thesis (Masters) |
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| Additional Information: | 261710014 |
| Uncontrolled Keywords: | Chitosan, Hydrogel Matrix, Licorice, Targeting Helicobacter Pylori. |
| Subjects: | PHARMACY > Pharmaceutics |
| Depositing User: | Ramakrishnan J |
| Date Deposited: | 23 May 2022 09:27 |
| Last Modified: | 23 May 2022 09:42 |
| URI: | http://repository-tnmgrmu.ac.in/id/eprint/20174 |
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