Sreelakshmi, M (2022) A Study of Association of Serum Calcium Level in Pregnant Females with Hypertensive Disorders in Government Vellore Medical College and Hospital, Vellore. Masters thesis, Vellore Government Medical College, Vellore.
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Abstract
INTRODUCTION: Preeclampsia is a frequent disease with an incidence of 5 to 7% among the general population. Preeclampsia is associated with a five-fold increase in perinatal mortality. In general, there is disagreement about many aspects of hypertensive disorders of pregnancy, including the diagnosis, classification, and management. Pregnancy is a period of high calcium demand because of fetal requirement. Many compensatory mechanisms comes into action to prevent calcium depletion from maternal skeletal reserves, like increased absorption, reduced renal losses, etc. But in pre-eclampsia, all these compensatory mechanisms tend to function abnormally. The studies have shown a strong correlation of calcium with preeclampsia. It has been proven that inverse association exists between calcium intake and development of hypertension during pregnancy. This study intends to find the serum calcium level and its association with hypertensive disorders in pregnancy. AIM OF THE STUDY: 1) Identify the prevalence of hypocalcemia in pregnant females with hypertensive disorders of pregnancy. 2) Assess the compliance of calcium intake in the study group. METHODOLOGY: 100 patients who were diagnosed, or highly suspected to have hypertensive disorders of pregnancy, were selected randomly from the outpatient/in-patient wards of the obstetrics and gynecology department. Informed consent was obtained, and data collected based on the preformed questionnaire. Required investigations were done, after general and systemic examination. Of importance, blood pressure, corrected calcium, urine protein (by dipstick) were checked in all the patients. Compliance of drug intake was assessed from the questionnaire. Analysis was done, to find the average calcium level among the study population, and its correlation between severity of the disease. RESULTS: Statistical analysis was carried out to find any association between serum calcium and severity of the disease. The mean calcium level varied significantly (reduction in the level) across the disease spectrum, namely, gestational hypertension, pre-eclampsia, and pre-eclampsia with severe features. Analysis also revealed significant association between serum calcium and other parameters, like bloop pressure, proteinuria. Compliance of drug intake was assessed, and there was significant association between compliance and the severity of the disease. CONCLUSION: The findings of this study show that, there was significant association between serum calcium and hypertensive disorders of pregnancy, and its severity. Drug intake in the community was an important contributing factor, towards reducing the risk of developing severe disease.
| Item Type: | Thesis (Masters) |
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| Additional Information: | 201811659 |
| Uncontrolled Keywords: | Association, Serum, Calcium Level, Pregnant Females, Hypertensive Disorders, Government Vellore Medical College and Hospital, Vellore. |
| Subjects: | MEDICAL > General Medicine > MEDICAL > General Medicine |
| Depositing User: | Thavamani K |
| Date Deposited: | 23 May 2022 17:26 |
| Last Modified: | 09 Jan 2024 11:28 |
| URI: | http://repository-tnmgrmu.ac.in/id/eprint/20165 |
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