Behavioural Manifestations in patients with Alzheimer’s Disease - A Cross Sectional study.

Karpagam, V (2007) Behavioural Manifestations in patients with Alzheimer’s Disease - A Cross Sectional study. Masters thesis, Madras Medical College, Chennai.


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INTRODUCTION: WHO defines dementia as a “syndrome due to Disease of brain, usually of a chronic progressive nature, in which There is disturbance of multiple cortical functions, calculations, Learning capacity, language and judgement. Consciousness is not Clouded. Impairments in cognitive functions are commonly Accompanied, and occasionally preceded by emotional control, Social behaviour and motivation”. Dementia is defined as “ the development of Multiple cognitive deficits that include memory impairment and at Least one of the following: aphasia, apraxia, agnosia, or a disturbance In executive functioning, where executive functioning involves Selection of key information and behaviours for problem solving and The inhibition of inappropriate responses”(DSM IV, TR). The most common causes of dementia in Individuals older than 65 years of age are: Alzheimer’s disease, Vascular dementia and mixed vascular and Alzheimer’ s disease, of Which Alzheimer’s disease accounts for approximately 60% of all Dementias. The prevalence of Alzheimer’s disease is 3 to 5% of People older than 65 years of age and as much as 50% of people Older than 85 years of age. The female to male ratio is approximately 2:1. Patients with Alzheimer’s disease display Characteristic cognitive and non-cognitive symptoms over the course Of the illness. Neuropsychiatric symptoms may be prominent at Presentation or emerge later in the course. Almost all patients are Affected at some point in their disease. Neuropsychiatric symptoms in Alzheimer’s disease have significant consequences. Disorders such As depression, anxiety, and psychosis clearly affect the quality of life Of the patient. Besides being a source of considerable stress, Caregiver burden and potential injury, such disturbances are Associated with increased use of psychotropic medications, patient And caregiver abuse. Non-cognitive symptoms are associated with an Increased risk for institutionalization, which carries with it financial Consequences for the individual and for society. Characteristics of Neuropsychiatric symptoms In Alzheimer’s disease include the following: They may be the sentinel event heralding the onset of Alzheimer’s disease. Several types of symptoms may occur simultaneously, Fluctuate and recur over the course of illness. They tend to become more frequent as the disease progresses. They are associated with rapid cognitive decline and worsen Function. They may lead to institutionalization. Importantly, these Neuropsychiatric symptoms may improve With cholinergic therapy, disease modifying therapy and Psychotropic agents. The Neuropsychiatric symptoms play an Important role in the diagnosis and management of Alzheimer’s Disease. Early identification and treatment of these symptoms Reduces patient’s suffering, caregiver burden and delay Institutionalization.

Item Type: Thesis (Masters)
Uncontrolled Keywords: Behavioural Manifestations ; patients ; Alzheimer’s Disease.
Subjects: MEDICAL > Psychiatry
Depositing User: Subramani R
Date Deposited: 19 Aug 2017 03:27
Last Modified: 19 Aug 2017 03:27

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