Anburajan, S (2023) Effect of Microcytic Anaemia on Glycosylated Hemoglobin A1c in Non Diabetic Adults. Masters thesis, Stanley Medical College, Chennai.
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Abstract
BACKGROUND: Many studies have shown that the level of HbA1c can be altered by various other factors apart from blood glucose values. One such factor is the quantity of iron in the blood. So, iron deficiency anemia, which is the most common of the microcytic anemias plays a significant role in the measurement of HbA1c. Thus, India being the diabetic capital of the world, along with microcytic anemia prevailing so common in the community, needs certain measures to prevent false reporting of diabetic cases. AIM OF THE STUDY: To analyse the effect of microcytic hypochromic anaemia on HbA1c levels in non-diabetic individuals. OBJECTIVES: 1. To estimate HbA1c levels among non-diabetic adults with microcytic anaemia. 2. To compare it with HbA1c levels among age and gender matched non-diabetic controls and thereby establishing a correlation between MCV and the levels of HbA1c, if any. METHODS: We did a case control study comprising of 30 cases and 30 controls. Anemic patients were taken as cases while age and gender matched non anemic patients were taken as controls. Mean HbA1c were measured in them and the difference is evaluated. RESULTS: The difference between the mean HbA1c values of cases and controls is 1.39%. The HbA1c values were significantly higher in the cases group than the control group which is statistically significant with a ‗ p value of < 0.001. CONCLUSION: Based on our study we can safely conclude that microcytic anemia definitely has an impact on the HbA1c. As MCV decreases in patients with microcytic anemia, HbA1c tends to rise. Thus, microcytic anemia, if present must be corrected before making any diagnostic or therapeutic decision based on the HbA1c levels.
| Item Type: | Thesis (Masters) |
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| Additional Information: | 200120101002 |
| Uncontrolled Keywords: | Hba1c, microcytic anemia. |
| Subjects: | MEDICAL > General Medicine > MEDICAL > General Medicine |
| Depositing User: | Thavamani K |
| Date Deposited: | 24 May 2022 00:44 |
| Last Modified: | 20 Mar 2024 04:36 |
| URI: | http://repository-tnmgrmu.ac.in/id/eprint/20153 |
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