Rasika, P (2019) Formulation and Evaluation of Transdermal Patch of Cissus Quadrangularis L for the Management of Arthritis. Masters thesis, Periyar College of Pharmaceutical Sciences, Tiruchirappalli.
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Abstract
Six batches of (HPE1, HPE2, HPE3&HPF1, HPF2, HPF3) Ethanolic Extract Transdermal patches were prepared by solvent casting technique. The various formulation parameters, Drug-Polymer ratios and permeation enhancers were optimized to get thin, transparent, smooth, stable and high permeable transdermal patches. HPTLC finger printing of Cissus quadrangularis L showed that presence of flavonoids, alkaloids and glycosides. The FTIR graphs of active constituents, excipients and formulations showed that there is no extra peak (or) broadening of peaks were observed and thus it indicates that there is no incompatibility between drug and excipients. From the optimization, best 2 formulations HPE1& HPF2 were selected based on physicochemical evaluation and in vitro diffusion study 0.3ml of glycerin was added as plasticizer to produce a flexible patch without having major influence on their diffusion property. If the amount exceeds, the film loses its flexibility and become stiff. The plasticizer diffuses through the patch and softens the polymer particles. This softening promotes latex coalescence and patch formation. All the six batches were evaluated for Percentage Moisture uptake, Percentage Moisture content, Thickness, Folding Endurance, Percentage Drug content, Percent Elongation, Tensile strength. The formulations HPE1 & HPE2 showed maximum % Moisture uptake, Moisture content, Thickness, folding endurance, % Drug content, Percent elongation, Tensile strength No significant difference in drug content was observed between the patches among the six formulations. This indicates the homogenous dispensing of drug during the patch preparation. The data obtained from in vitro diffusion profile of selected formulations were fitted with various kinetic equations to determine the mechanism of drug diffusion and diffusion rate as indicated by higher correlation coefficients (r2). The drug diffusion from HPE1 & HPF1 follows zero order and non-fickian diffusion. These findings indicates that the drug diffusion from the HPE1 & HPF1 patch was diffusion controlled. From the results of Comparative in vitro diffusion and physicochemical studies, HPE1 & HPF1 was concluded as best formulation and this 2 formulation HPE1 showed the better in vitro release. Then the 2 formulation were subjected to skin irritation studies. Skin irritation study results indicated the formulation of Transdermal patch of HPE1 have shown minimally perceptible erythema (faint pink) .Thus it concluded that the Transdermal patch have acceptable skin complications when compared to control. The control did not show any skin irritation. The ex vivo studies results showed 60.32% of drug diffusion at the end of 8 hr. It concluded the controlled diffusion property of through the skin The stability studies results showed that there is no significant change from its initial nature till the period of three months at 40˚C ±2˚C/75 5% RH. The present work has achieved the objectives of formulation of Transdermal patch of Ethanolic extract of Cissus quadranularis L by using different grade of polymers. The diffusion kinetics confirms that the formulation followed zero order, non-fickian diffusion model.
| Item Type: | Thesis (Masters) |
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| Additional Information: | 261710201 |
| Uncontrolled Keywords: | Formulation, Evaluation, Transdermal Patch, Cissus Quadrangularis L, Management, Arthritis |
| Subjects: | PHARMACY > Pharmaceutics |
| Depositing User: | Ramakrishnan J |
| Date Deposited: | 20 May 2022 05:56 |
| Last Modified: | 20 May 2022 05:56 |
| URI: | http://repository-tnmgrmu.ac.in/id/eprint/20139 |
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