David, S (2019) Formulation and Compatibility of Admixture Study for Sodium Nitroprusside Infusion. Masters thesis, RVS College of Pharmaceutical Sciences, Coimbatore.
|
Text
261107919david.pdf Download (1MB) | Preview |
Abstract
Admixture study was performed by diluting exhibit batch samples of Sodium Nitroprusside Injection 50 mg/2mL-2mL and RS NITROPRESS samples with 5% w/v Dextrose injection diluents present in 250 mL and 1000 mL infusion bags, accordingly physical and chemical test parameters were evaluated. ➢ Initial time point Admixed samples in 5% w/v Dextrose injection 250 mL and 1000 mL infusion bag, are analysed at 0 hrs and 24 hrs after dilution for the test parameter Description, pH, Assay and Related Substances and the results are found within the acceptance criteria of specification. CONCLUSION: ➢ Based on the obtained results, it is confirmed that the admixed generic product is stable for 24 hours, after admixing with 5% Dextrose injection in 250 mL infusion bag and 1000 mL infusion bag. ➢ The results obtained for admixture study of RS - NITROPRESS injection batch Number: 690103F were compared with the results as obtained for admixture study of generic product batche for Sodium Nitroprusside Injection 50 mg/2mL-2mL, Batch and were found to be comparable.
| Item Type: | Thesis (Masters) |
|---|---|
| Additional Information: | 261710752 |
| Uncontrolled Keywords: | Formulation, Compatibility, Admixture Study, Sodium Nitroprusside Infusion |
| Subjects: | PHARMACY > Pharmaceutics |
| Depositing User: | Ramakrishnan J |
| Date Deposited: | 19 May 2022 07:08 |
| Last Modified: | 19 May 2022 07:08 |
| URI: | http://repository-tnmgrmu.ac.in/id/eprint/20125 |
Actions (login required)
 |
View Item |
