Sindhu Chowdary, M (2019) Design and Development of Press Coated Pulsatile Release of Ketoprofen Tablets. Masters thesis, K.K.College of Pharmacy, Chennai.
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Abstract
The present study involved the Formulation and evaluation of Ketoprofen pulsatile tablets by using different polymers and in combination of synthetic and natural polymers. Organoleptic properties, Solubility, compatibility studies was carried out and found to be satisfied. By preformulation studies of granules of core tablet, angle of repose and compressibility index was found to be in the range, shown excellent flow property for compression. Evaluations studies was performed for the core tablet included friability, hardness, weight variation fall within SD±2%, Content uniformity was complies Evaluation studies of coated tablet, friability, hardness, weight variation fall within SD±2%. In vitro dissolution studies were performed for the formulation F1 to F9 and the formulation 8 gave a Pulsatile drug release at the end of 6th hrs. Here at once drug was released completely after predetermined time. The Stability studied was carried out for the formulation 8 for two months as per ICH guidelines and found to be stable. Conclusion Although sustained and controlled drug delivery systems have gained a lot of success and application in field of medication, these systems fail to deliver drug according to circadian behavior of diseases for which pulsatile systems are beneficial. There is a constant need for new delivery systems that can provide increased therapeutic benefits to the patients. Pulsatile drug delivery is one such system that, by delivering drug at the right time, right place, and in right amounts, holds good promises of benefit to the patients suffering from chronic problems like arthritis (In world mostly women are suffering with rheumatoid arthritis. Based upon the research F8 formulation was shown pulsatile release after completion of 6 hr i.e was suitable for the treatment of rheumatoid arthritis.
| Item Type: | Thesis (Masters) |
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| Additional Information: | 261710501 |
| Uncontrolled Keywords: | Design, Development, Press Coated Pulsatile Release, Ketoprofen Tablets |
| Subjects: | PHARMACY > Pharmaceutics |
| Depositing User: | Ramakrishnan J |
| Date Deposited: | 19 May 2022 06:48 |
| Last Modified: | 19 May 2022 06:48 |
| URI: | http://repository-tnmgrmu.ac.in/id/eprint/20123 |
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