Nikhil, V Jain (2023) A Study on Clinical Profile and Outcome of Primary Membranous Nephropathy: A Single Centre Experience. Masters thesis, Madras Medical College, Chennai.
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Abstract
BACKGROUND: Membranous nephropathy is among the most common causes of nephrotic syndrome in adults who are not diabetic. Among primary and secondary membranous nephropathy, primary membranous nephropathy is more common. AIMS OF THE STUDY: 1. To study the outcomes of various immunosuppressive therapies in patients with primary membranous nephropathy. 2. To study the adverse event of immunosuppressive therapies. MATERIALS AND METHODS: The patients with primary membranous nephropathy were included in the study based on inclusion and exclusion criteria. Their demographic profile were recorded and analysed. Also, the clinical and biochemical parameters were recorded. Based on the risk stratification patient were initiated on conservative line of treatment or immunosuppressive therapy and their response to treatment and complications if any were studied. RESULTS AND CONCLUSION: A total of 31 patients were included in the study. 48.4% ,41.9% and 9.7% of the population were low risk, moderate risk and high risk population respectively. Out of 31 patients, 28 patients were on conservative management and 3 patients were started on modified Ponticelli regimen since they were under high risk groups. After 6 months of conservative management 16.1% (5/31) had spontaneous remission. A total of 26 patients had received modified Ponticelli regimen. At end of 12 months after completion of modified Ponticelli regimen, 69.2% (18/26) had complete remission, 3.8% (1/26) had partial remission, 26.9% (7/26) had no remission. The 8 patients who had persistent proteinuria were initiated on tacrolimus. After 12 months of the treatment 1 patient had complete remission, 2 patient had partial remission. The modified Ponticelli regimen was tolerated well by the patients.
| Item Type: | Thesis (Masters) |
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| Additional Information: | 200120100520 |
| Uncontrolled Keywords: | Clinical Profile, Outcome, Primary Membranous Nephropathy, Single Centre Experience. |
| Subjects: | MEDICAL > General Medicine > MEDICAL > General Medicine |
| Depositing User: | Thavamani K |
| Date Deposited: | 24 May 2022 00:40 |
| Last Modified: | 17 Mar 2024 14:12 |
| URI: | http://repository-tnmgrmu.ac.in/id/eprint/20113 |
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