Govindaraj, S (2019) Formulation and Invitro Evaluation of Norfloxacin Gastric Floating Drug Delivery System. Masters thesis, J.K.K.Nattraja College of Pharmacy, Kumarapalayam.
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Abstract
The purpose of this investigation study was to design a Gastric floating drug delivery system of Norfloxacin by using easily available inexpensive natural and semi synthetic polymers. Norfloxacin has favorable characters to be formulated as Controlled GFDDS, it is well absorbed throughout the whole gastrointestinal tract, Norfloxacin is least absorbed from the lower part of the gastrointestinal tract and is better absorbed from the stomach. This drug has a repetitive dose schedule (400 mg twice daily), short biological half-life (3–4 h) and reduced bioavailability(30–40%) . Hence selected as model drug, such as optimum t1/2, multiple doses per day are required for the treatment it is a potential drug in treating various serious G.I diseases like gastritis, urinary tract infections, prostatitis and gonorrhea etc, it has comparatively less side effects shown by other fluoroquinolene drugs , etc , single dose is enough compared to overall multiple doses given in a day to maintain the peak plasma level and therapeutic concentration in blood. Floating tablets of Norfloxacin were prepared by using various natural and semi synthetic polymers such as guar gum, sodium CMC, HPMC K15M. These polymers were evaluated for their gel forming properties. Sodium bicarbonate was incorporated as a gas-generating agent. The floating tablets were evaluated for uniformity of weight, hardness, friability, drug content, in vitro buoyancy and dissolution studies. Guar Gum is a potential excepient which is available easily and is inexpensive, this excipient has very good swelling and binding properties when comes in contact with fluids like water and gastric fluids. Hence selected as a binder in the present study. Sodium CMC is another polymer easily available, it possess good potential in pharmaceutical preparations as it has good swelling index and it is also used as a binding agent, so it can be safely taken in orally and not toxic in nature, it is from natural source and used prefearbly. HPMC K15M is a Semi Synthetic controlled release polymer, and hence selected to compare with natural polymers. Formulations were prepared by using natural and semi synthetic polymer and optimized by using direct compression method. The prepared tablets exhibited satisfactory physico- chemical characteristics. All the prepared batches shown good in vitro buoyancy studies and continuous till 24 hours. CONCLUSION From the present study, the following conclusions were observed: Gastric Floating Drug Delivery (GFDD) systems of Norfloxacin with shorter lag time can be prepared by direct compression method using guar gum, HPMC K15M, sodium CMC individual and mixed polymers and NaHCO3 as gas generating agent. All the prepared tablet formulations were found to be good without capping and chipping. The in vitro dissolution profiles of all the prepared GFDDS formulations of Norfloxacin were found to extend the drug release over a period of 7 to 12 hours . Release of Norfloxacin from the GFDDS formulations follows zero order kinetics (0.97 to 0.99).When drug release data fitted to Korsmeyer equation, the values of slope ‘n’ (0.678 to 0.900) indicated that the drug release was by non-fickian mechanism. IR spectroscopic studies indicates no drug-excipient interaction in the prepared formulations. Comparing the all formulations, GFDDS formulation of F3 was considered as an ideal formulation which exhibited 99.37% of drug release in 12 hours, and floating lag time of 130 seconds with a floating time of 24 hours.
| Item Type: | Thesis (Masters) |
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| Additional Information: | 261710260 |
| Uncontrolled Keywords: | Formulation, Invitro Evaluation, Norfloxacin Gastric Floating Drug Delivery System |
| Subjects: | PHARMACY > Pharmaceutics |
| Depositing User: | Ramakrishnan J |
| Date Deposited: | 19 May 2022 05:29 |
| Last Modified: | 19 May 2022 05:29 |
| URI: | http://repository-tnmgrmu.ac.in/id/eprint/20110 |
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