Application of immunohistochemistry in the diagnosis and classification of acute leukemia

Priya, S (2013) Application of immunohistochemistry in the diagnosis and classification of acute leukemia. Masters thesis, PSG Institute of Medical Sciences & Research, Coimbatore.

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Abstract

Acute leukemias are characterized by neoplastic proliferation of hematopoietic stem cells and accumulation of blasts and immature cells in the bone marrow. They are broadly classified into two main groups viz., Acute Myeloid Leukemia (AML) and Acute Lymphoid Leukemia (ALL), based on the cellular presentation of the primary stem cell defect. If maturation and differentiation of common myeloid progenitor cell is defective, the leukemia is classified as Acute Myeloid Leukemia and is characterized by clonal expansion of myeloid blasts. On the contrary if the maturation and differentiation of common lymphoid progenitor cell is defective, the leukemia is classified as Acute Lymphoid Leukemia and is characterized by clonal expansion of lymphoid blasts in peripheral blood, bone marrow or other tissues. The World Health Organization (WHO) further sub classifies these neoplasms based on morphology, cytochemistry, immunophenotyping, cytogenetic and molecular genetic studies. Borowitz MJ, Bene MC, Harris NL, Porwit A, Matutes E. Acute leukemias of ambiguous lineage. In: Swerdlow SH, campo E, Harris NL, Jaffe ES, Pileri SA, Stein H, et al. (Eds): WHO Classification of Tumours of Haematopoietic and Lymphoid Tissues. 4th edition. IARC: Lyon 2008.150-55. 55. Browman GP, Neame PB, Soamboonsrup P. The contribution of cytochemistry and immunophenotyping to the reproducibility of the FAB classification in acute leukemia. Blood. Oct 1986;68(4):900-5.

Item Type: Thesis (Masters)
Uncontrolled Keywords: Application immunohistochemistry; diagnosis and classification of acute leukemia
Subjects: MEDICAL > Pathology
Depositing User: Subramani R
Date Deposited: 21 Jun 2017 11:23
Last Modified: 22 Jun 2017 05:53
URI: http://repository-tnmgrmu.ac.in/id/eprint/201

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