Michael Rajam Geetha, S (2016) Serum leptin levels in rheumatoid arthritis. Masters thesis, Madras Medical College, Chennai.
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Abstract
The fat stores in our body secrete many hormones and cytokines that not only regulate the energy balance but also regulate the inflammatory and immune responses. Among them leptin has been investigated widely as a proinflammatory cytokine in the pathogenesis of several inflammatory autoimmune diseases. Therefore this study was designed to measure the serum leptin levels in Rheumatoid Arthritis(RA) patients and to compare it with healthy controls and also to correlate serum leptin levels in Rheumatoid arthritis patients with their disease activity. Methodology: Sixty adult RA patients and 30 sex and age matched healthy controls were selected for this case control study. Serum leptin, C-reactive protein, lipid profile, uric acid, urea, creatinine and ESR were estimated in the study subjects. The disease activity in RA patients was assessed using the DAS 28(3) scoring system. Body mass index (BMI) was calculated for both RA patients and controls using Quetelet index. Estimation of serum leptin levels in RA patients and controls was done using DRG Leptin ELISA Kit. Results: RA patients showed statistically significant higher mean serum leptin level than healthy controls (48.78+ 32.00ng/mL versus 11.94+6.11ng/mL respectively, p=<0.001). However no significant correlation was observed in RA patients between serum leptin level and disease activity (p= 0.240). But the serum leptin level showed a statistically significant positive correlation with body mass index (p= 0.001) and Creactive protein (p= 0.001). Conclusion: As the serum leptin levels were significantly higher in the RA patients than in the controls it is understood that leptin plays a pivotal role in the pathogenesis of RA as a proinflammatory cytokine. However no correlation was observed between serum leptin levels and disease activity of the RA patients. But the serum leptin levels correlated well with body mass index indicating that the body fat stores can also decide upon the incidence of RA. The study also demonstrated a good correlation between serum leptin levels and C- reactive protein proving leptin as a inflammatory marker.
| Item Type: | Thesis (Masters) |
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| Uncontrolled Keywords: | Rheumatoid Arthritis ; Serum Leptin ; DAS28(3) ; BMI ; C-reactive protein. |
| Subjects: | MEDICAL > Biochemistry |
| Depositing User: | Punitha K |
| Date Deposited: | 20 Jul 2017 09:47 |
| Last Modified: | 06 May 2018 14:42 |
| URI: | http://repository-tnmgrmu.ac.in/id/eprint/2008 |
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