Saranya, P (2019) In Silico Approaches for the Identification of Novel Inhibitors for Mitochondrial Prostaglandin E Synthase (Mpges) – 1. Masters thesis, J.K.K.Nattraja College of Pharmacy, Kumarapalayam.
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Abstract
In the present study, an in silico approach using similarity search and molecular docking methods are utilized to identify new inhibitors of mPGES-1. The initial study revealed from these two approaches top 5 molecules found to occupy the binding pocket of mPGES-1 and form electrostatic interaction with amino acids and water molecules. The selected 5 molecules also showed favourable docking score and interaction with the enzyme. These compounds can be further considered in-vitro testing. The approach opens up new scaffolds as inhibitors of mPGES-1 .
| Item Type: | Thesis (Masters) |
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| Additional Information: | 261715202 |
| Uncontrolled Keywords: | In Silico Approaches, Identification, Novel Inhibitors, Mitochondrial Prostaglandin E Synthase (Mpges) – 1 |
| Subjects: | PHARMACY > Pharmaceutical Chemistry |
| Depositing User: | Ramakrishnan J |
| Date Deposited: | 12 May 2022 06:12 |
| Last Modified: | 12 May 2022 06:12 |
| URI: | http://repository-tnmgrmu.ac.in/id/eprint/20023 |
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