In Silico Approaches for the Identification of Novel Inhibitors for Mitochondrial Prostaglandin E Synthase (Mpges) – 1

Saranya, P (2019) In Silico Approaches for the Identification of Novel Inhibitors for Mitochondrial Prostaglandin E Synthase (Mpges) – 1. Masters thesis, J.K.K.Nattraja College of Pharmacy, Kumarapalayam.

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Abstract

In the present study, an in silico approach using similarity search and molecular docking methods are utilized to identify new inhibitors of mPGES-1. The initial study revealed from these two approaches top 5 molecules found to occupy the binding pocket of mPGES-1 and form electrostatic interaction with amino acids and water molecules. The selected 5 molecules also showed favourable docking score and interaction with the enzyme. These compounds can be further considered in-vitro testing. The approach opens up new scaffolds as inhibitors of mPGES-1 .

Item Type: Thesis (Masters)
Additional Information: 261715202
Uncontrolled Keywords: In Silico Approaches, Identification, Novel Inhibitors, Mitochondrial Prostaglandin E Synthase (Mpges) – 1
Subjects: PHARMACY > Pharmaceutical Chemistry
Depositing User: Ramakrishnan J
Date Deposited: 12 May 2022 06:12
Last Modified: 12 May 2022 06:12
URI: http://repository-tnmgrmu.ac.in/id/eprint/20023

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