Sathish, A (2019) Design, Synthesis, Characterization and Biological Evaluation of Some Novel 2,4-Substituted Thiazolidine Derivatives as Antitubercular Agents. Masters thesis, College of Pharmacy, Madurai Medical College, Madurai.
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Abstract
Molecular design: The novel molecule of 2,4-substituted thiazolidine derivatives are designed by using some software such as chemsketch, molinspiration and swiss ADME and determined the important molecular properties such as log P, log s playing a important role in their biological activity. And also determined the compounds obeys the lipinki’s rule of five for the oral administration capability. Synthesis : The designed compounds are synthesized by the variouse aldehyde react with the Lcysteine to formed the carboxylic acids. It further treated with the O-phenylene diamine in presence of ammonium chloride and ethanol. Characterization : The synthesized compounds are characterization done by determined the physical data such as molecular formula, IUPAC name, physical appearance,percentage yield ,Rfvalue, melting point,solubility and spectral data such as IR-spectrum, NMR-spectrum, MASS-spectrum confirmed the structure of the compounds. Biological Evaluation : The synthesized compounds are screened the antitubercular activity against the two type of M.tuberculosis such as M.tuberculosis H37Rv and M.tuberculosis MRD strain in 100μg/ml, 500μg/ml by LRP assay method and different concentration of compounds screened against the Mtb.H37Rv by micro plate alamar blue assay method. CONCLUSION : The compound C1 sensitive at 100μg/ml, compounds C2,C3 & C5 senstive at 50μg/ml against the Mtb.H37Rv and good activity. Today, The tuberculosis is one of the major death forming disease along with the HIV positive. So, Further development of the novel 2,4-substituted thizolidine derivatives may be used to achieved the better treatment for the Tuberculosis in future.
| Item Type: | Thesis (Masters) |
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| Additional Information: | 261715754 |
| Uncontrolled Keywords: | Design, Synthesis, Characterization, Biological Evaluation, Novel 2,4-Substituted Thiazolidine Derivatives, Antitubercular Agents |
| Subjects: | PHARMACY > Pharmaceutical Chemistry |
| Depositing User: | Ramakrishnan J |
| Date Deposited: | 09 May 2022 10:36 |
| Last Modified: | 09 May 2022 10:36 |
| URI: | http://repository-tnmgrmu.ac.in/id/eprint/20006 |
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