Analysis of MLH1 and MLH12 Immunohistochemistry in Colorectal Carcinomas

Pavethira, P (2013) Analysis of MLH1 and MLH12 Immunohistochemistry in Colorectal Carcinomas. Masters thesis, PSG Institute of Medical Sciences & Research, Coimbatore.


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40% of the colorectal cancers studied lacked the expression of mismatch repair proteins (MMR) ,MLH1 and MSH2 which is significantly high when compared to other studies done in India. � Loss of MMR protein was found to occur in older age group(7th decade). � Among the various variables studied, only histological type and grade of the tumor showed statistically significant correlation. � MSH2 negative tumors were mostly poorly differentiated adenocarcinomas which included mucinous and signet ring cell carcinomas. � Immunohistochemical staining for MMR proteins can be used as a reliable tool to detect MSI in colorectal cancers. This will help in the identification of these patients whose relatives need to be screened periodically to prevent the occurrence of colorectal cancer in them. � The current study has tested only for the two common MMR proteins. Further studies are required to identify the occurrence of rare MMR proteins also.

Item Type: Thesis (Masters)
Uncontrolled Keywords: MLH1; MLH12; immunohistochemistry; Colorectal; Carcinomas; Analysis
Subjects: MEDICAL > Pathology
Depositing User: Subramani R
Date Deposited: 21 Jun 2017 11:17
Last Modified: 27 Mar 2020 02:12

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