Dharshana, M (2022) Assessing the Effect of Nonsurgical Periodontal Treatment on Serum Nitric Oxide Levels in Smoke and Smokeless Tobacco Users with Chronic Periodontitis: A Clinical study. Masters thesis, Vivekananda Dental College For Women, Tiruchengode.
Full text not available from this repository.Abstract
INTRODUCTION: Periodontitis is a chronic inflammatory condition that develops by the interactions of the host immune system and the dysbiotic subgingival microbiota. Along with bacterial stimuli, the tobacco usage increases the overall oxidative burden in the body, as it has more amounts of free radicals and it can also increase the reactive nitrogen species in the oral cavity, that may be the cause of periodontal tissue destruction. The different types of tobacco, either it may be a smoking/smokeless may give as one of the major risk factors of periodontal inflammation. The treatment option for periodontal disease is still focused on effective mechanical debridement on tooth surface such as scaling and root planning. By removing the local factors, the non surgical periodontal therapy (phase I therapy) will decrease overall bacterial load in the oral cavity, that will help to decrease the oxidative stress in the periodontal health. AIM OF THE STUDY: The aim of the study was to assess the effect of nonsurgical periodontal treatment on serum nitric oxide levels in smoke and smokeless tobacco users with chronic periodontitis MATERIALS AND METHODS: 90 volunteers with chronic periodontitis aged between 30-55 years were classified into 3 groups with 30 patients in each group. They were Group A (chronic periodontitis), Group B (chronic periodontitis + smoking tobacco users) and Group C (chronic periodontitis + smokeless tobacco chewers. After thorough clinical examination, plaque index (PI), gingival index (GI), periodontal probing depth (PPD) and clinical attachment level (CAL) were recorded, serum samples were collected from the patients at baseline and after non surgical periodontal therapy to evaluate nitric oxide level by ELISA method. RESULTS: Chronic periodontitis patients with non-smoker, smoker and tobacco chewer showed the presence of nitric oxide level in serum. The nitric oxide level was great in smokers and tobacco chewers as it showed positive correlation with tobacco users. After 6 weeks of non-surgical periodontal therapy all the parameters for each groups of Group A, Group B, Group C were significantly reduced (p<0.05) from the baseline with 95% confidence interval for mean. CONCLUSION: Non-surgical periodontal therapy showed valuable effect in decreasing the nitric oxide level with no significancy between non-smoker, smoker and tobacco chewer in periodontitis patients. Thus, the concentration of nitric oxide in serum can be used as a suitable biomarker in the inflammatory periodontium.
| Item Type: | Thesis (Masters) |
|---|---|
| Additional Information: | 241913502 |
| Uncontrolled Keywords: | Periodontitis, Smokers, Tobacco chewers, Nitric oxide, ELISA. |
| Subjects: | DENTAL > Periodontology |
| Depositing User: | Subramani R |
| Date Deposited: | 08 May 2022 14:39 |
| Last Modified: | 13 May 2022 07:11 |
| URI: | http://repository-tnmgrmu.ac.in/id/eprint/19935 |
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