PAX 5 expression in Lymphomas and its correlation with clinical features and other Panel of markers in lymphomas

Lakshmikanth, R M (2013) PAX 5 expression in Lymphomas and its correlation with clinical features and other Panel of markers in lymphomas. Masters thesis, PSG Institute of Medical Sciences & Research, Coimbatore.


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“Lymphomas are malignant neoplasms of lymphoreticular system” as quoted by John K C Chan in the book ‘Diagnostic histopathology of tumors’ [1]. They present as a solid mass generally. The incidence of this tumor is increasing worldwide as well as in India and is not a rare tumor anymore. The national cancer registry programme in its first all India report in the year 2001-2002 claims an incidence of 5.1 per one lakh population. [2] Painless lymph node enlargement confined to one lymph node region or involving multiple lymph node regions is the commonest clinical presentation of a lymphoma. Apart from the nodes, lymphomas can involve skin, gastrointestinal tract, salivary glands, nasopharynx, paranasal sinuses, lung, thyroid, ocular adnexa, kidneys, adrenals, breast etc. When the lymphomas involve the sites other than the nodes they are called extranodal lymphomas. [1] Lymphomas when suspected clinically needs to be confirmed histologically. A confirmatory diagnosis of lymphoma is made by a histological examination, sometimes aided by ancillary techniques like immunohistochemistry, flow cytometry and genetic studies. The lymphomas can be broadly categorised as Hodgkin’s lymphoma (HL) and Non Hodgkin’s lymphoma (NHL). Based upon the principles adopted in REAL classification, WHO has classified about 58 lymphomas under the following six broad groups. Shinsuke lida, Pulivarthi H. Rao, Palanisamy Nallasivam et al. The t(9; 14)(p13; q32) Chromosomal Translocation Associated With Lymphoplasmacytoid Lymphoma Involves the PAX-5 Gene. Blood 1996; 88: 4110-4117 52. Seetharaman Balasenthil, Anupama E Gururaj, Amjad H Talukder. Identification of Pax5 as a target of MTA1 in B cell lymphomas. Cancer res 2007;67(15):7132-7138 53. Gilles A. Robichaud, Michel Nardini, Mark Laflamme et al. Human Pax-5 C-terminal Isoforms Possess Distinct Transactivation Properties and Are Differentially Modulated in Normal and Malignant B Cells. the journal of biological chemistry , 2004;279( 48) 49956–49963 54. Mengyong Yan, Nourredine Himoudi, Martin Pule, et al. Development of Cellular Immune Responses against PAX5, a Novel Target for Cancer Immunotherapy Cancer Res 2008;68:8058-8065

Item Type: Thesis (Masters)
Uncontrolled Keywords: PAX 5 expression Lymphomas; its correlation with clinical features other Panel markers in lymphomas;
Subjects: MEDICAL > Pathology
Depositing User: Subramani R
Date Deposited: 21 Jun 2017 11:05
Last Modified: 22 Jun 2017 05:48

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