A Histochemical & immunohistochemical study on helicobacter pylori associated chronic gastritis

Karthick Prabhu, R (2013) A Histochemical & immunohistochemical study on helicobacter pylori associated chronic gastritis. Masters thesis, PSG Institute of Medical Sciences & Research, Coimbatore.


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SUMMARY: To summarize, 1. In this study on 55 cases of H.pylori associated chronic gastritis, spanning 1 year duration there was MALE predominance with age group being 4th to 5th decade. 2. The common site being GASTRIC ANTRUM. 3. Comparing with routine H&E and Modified Giemsa, Antibody against H.pylori showed higher sensitivity exhibiting MARKED colonization in majority of cases, which were previously thought as MODERATE in Modified Giemsa. 4. On observing the pathological changes, we found predominantly LYMPHOID FOLLICLES in almost all cases. 5. Other features indicating H.pylori associated chronic gastritis such as Metaplasia (commonly Intestinal), villiform transformation were also noted. Though there are number of methods for detection of H.pylori, Histopathology is always the gold standard. To add it on, use of Immunohistochemistry would increase the specificity and also reduces the false negative results. Thus by using the H.pylori antibody in routine practice along with Modified Giemsa, the diagnosis could be made easily, more specifically and quickly. In the developing countries, though the feasibility is low due to cost, we would suggest that implementation of IHC as a routine in near future would help in providing an early diagnosis and appropriate treatment for H.pylori associated chronic gastritis.

Item Type: Thesis (Masters)
Uncontrolled Keywords: histochemical immunohistochemical study ; helicobacter pylori ; chronic gastritis.
Subjects: MEDICAL > Pathology
Depositing User: Subramani R
Date Deposited: 21 Jun 2017 10:56
Last Modified: 16 Jun 2018 01:41
URI: http://repository-tnmgrmu.ac.in/id/eprint/198

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