Expression of COX2 in Oral Epithelial Dysplasia and Oral Squamous Cell Carcinoma: An Immunohistochemical study

Deepika, E (2022) Expression of COX2 in Oral Epithelial Dysplasia and Oral Squamous Cell Carcinoma: An Immunohistochemical study. Masters thesis, Adhiparasakthi Dental College and Hospital, Melmaruvathur.

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Abstract

BACKGROUND: The cyclooxygenase-2 (COX-2) is an arachidonic acid metabolite that converts arachidonic acid to prostaglandins (PG), including PGE2, a key mediator of inflammation and angiogenesis. According to numerous literature evidence, it is believed that upregulated expression of COX 2 has been associated with human carcinogenesis and progression of cancer. COX 2 overexpression has also been found in precancerous lesions even before the expression of biomarkers of apoptosis and angiogenesis. With this background we conducted a study to evaluate the role of COX2 in the pathogenesis of epithelial dysplasia and oral squamous cell carcinoma. AIM OF THE STUDY: The aim of this study was to determine the immunohistochemical expression of COX2 in oral epithelial dysplasia and oral squamous cell carcinoma MATERIALS AND METHODS: A total of 30 paraffin embedded tissue blocks from the archives of department of oral pathology, consisting of ten cases each of previously diagnosed cases of Oral epithelial dysplasia, Oral Squamous cell carcinoma and Normal oral mucosa were included in the study. The tissue blocks were sliced into 3 μm thick sections and tissue sections were mounted on positively charged slides. Immunohistochemical staining of COX2 were performed. The intensity and area of staining was assessed and scored. The data obtained were statistically analyzed using SPSS software version 23.0. RESULTS: On evaluating and comparing COX2 intensity and area of staining among study groups, statistically significant values (p≤05) were obtained using Kruskal Wallis test. CONCLUSION: We conclude that the expression of COX2 can be used as a prognostic marker used to prevent the transformation of oral Premalignant lesions to oral squamous cell carcinoma.

Item Type: Thesis (Masters)
Additional Information: 241921401
Uncontrolled Keywords: Immunohistochemistry, COX2, Oral Epithelial Dysplasia and Oral squamous cell carcinoma.
Subjects: DENTAL > Oral Pathology and Microbiology
Depositing User: Subramani R
Date Deposited: 08 May 2022 08:59
Last Modified: 14 May 2022 07:08
URI: http://repository-tnmgrmu.ac.in/id/eprint/19783

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