Semporjothi, T (2022) Comparoison of Exhaled Carbon Monoxide Level with the Micronucleus frequency in the Buccal Mucosal Cells of Smokers: A Cross Sectional study. Masters thesis, Vivekananda Dental College For Women, Tiruchengode.
Full text not available from this repository.Abstract
INTRODUCTION AND AIM OF THE STUDY: Exhaled carbon monoxide levels were shown to be an effective tool in assessing smoking habit. Micronuclei were studied in the exfoliated buccal mucosal cells of smokers as a reliable marker of genotoxicity. This study compares the exhaled carbon monoxide level with the micronucleus frequency to find a correlation between them in smokers. METHODS: Exhaled carbon monoxide levels were measured in 75 current smokers using a portable device. Micronuclei were scored after staining the buccal cells by feulgen staining method. Data were subjected to statistical analysis. RESULTS: The carbon monoxide levels were increased (26 – 30 ppm) in participants smoked for 5 and 10 years of duration and in frequent smokers (3 or more times a day). Micronuclei scores were increased in above 50 years age group (4.10 ± 2.132), in 5 and 10 years of duration of smoking group (4.40 ± 2.066) and in frequent smokers smoking 3 and more than 3 times a day ( 4.0 ± 1.617). The correlations between them were found to be statistically highly significant. (p < 0.001) CONCLUSIONS: Current smoking status can be determined objectively by carbon monoxide levels in exhaled breath and combination of exhaled carbon monoxide levels and micronuclei count can be used as a tool to motivate smokers to quit smoking.
| Item Type: | Thesis (Masters) |
|---|---|
| Additional Information: | 241921453 |
| Uncontrolled Keywords: | Carbon monoxide, Cytology, Genotoxicity, Micronuclei, Smokers, Tobacco. |
| Subjects: | DENTAL > Oral Pathology and Microbiology |
| Depositing User: | Subramani R |
| Date Deposited: | 08 May 2022 08:49 |
| Last Modified: | 14 May 2022 06:39 |
| URI: | http://repository-tnmgrmu.ac.in/id/eprint/19777 |
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