Profile of patients with Thrombosis evaluated in a Tertiary Care Center.

Aysha Ali, A (2009) Profile of patients with Thrombosis evaluated in a Tertiary Care Center. Masters thesis, PSG Institute of Medical Sciences & Research, Coimbatore.


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A delicate balance exists between fibrin formation and fibrinolysis in vivo. Reduced blood flow, changes in the vessel wall and changes in blood composition result in disturbance of this balance, which favors fibrin formation and ultimately lead to formation of occlusive thrombi. Venous and arterial thrombosis are common diseases with an estimated incidence of 1 in 1000 individuals per year50 .Despite the growing insight in the pathogenesis of thrombophilia, the cause of many thrombotic episodes remain unknown. Although the causes are not always identified, several risk factors have been studied and it was observed that hypercoagulability is one of the triggers that alters the hemostasis. Hypercoagulability may occur due to defective naturally occurring anticoagulant mechanisms or due to heightened levels of procoagulant factors. Several risk factors have been identified like increased levels of coagulation factors-factor VIII, IX, XI, II and fibrinogen which are cumulatively explored by activated partial thromboplastin time used over the last 50 years as a standard screening test in clinical laboratories throughout the world. Several groups have identified elevated levels of factor VIII as an independent risk. The present study was aimed at examining risk factors involved in the pathogenesis of thrombosis in the Indian population. Review of literature has shown that most of the epidemiology studies to date with reference to thrombophilias, are confined to data derived from the European population. This study was done on 310 patients who presented with different thrombotic disorders. While the clinical utility of diagnostic testing for an inherited or acquired thrombophilia remains controversial, studies such as these hold the potential of further stratifying individual patients into high- and low-risk for incident and recurrent VTE. This in turn will help target prophylaxis to those who benefit the most and ultimately reduce the occurrence of venous thromboembolism. The commonest risk factor identified was increased Factor VIII:C levels, followed by antiphospholipid antibody and shortened activated partial thromboplastin time. Two hemolytic anemias – one genetic (sickle cell anemia) and the other an acquired membrane disorder (paroxysmal nocturnal hemoglobinuria) were also found to be associated with a tendency to thrombosis. 50% of the patients in this study who presented with thrombosis had no identifiable risk factors.

Item Type: Thesis (Masters)
Uncontrolled Keywords: Thrombosis; Tertiary Care Center
Subjects: MEDICAL > Pathology
Depositing User: Subramani R
Date Deposited: 21 Jun 2017 10:42
Last Modified: 22 Jun 2017 05:44

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