Mahesh Kumar, S (2019) Anti Urolithiatic Activity of Hydroalcoholic Extract of Apium Graveolens against Ethylene Glycol Induced Urolithiasis in Wistar Albino Rats. Masters thesis, Ultra College of Pharmacy, Madurai.
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Abstract
In conclusion, the presented data indicate that administration of the hydro alcoholic extract of Apium graveolens to rats in ethylene glycol induced lithiasis, reduced and prevented the growth of urinary stones, supporting the hill tribals’ claim regarding antilithiatic activity of the plants. Earlier studies reported that antilithiatic activity might be through an antioxidant activity and free radical scavenging principle(s). Hydro alcoholic extract of Apium graveolens are having Polyphenols- Tyrosol, Pyrogallol, saponins and Flavonoids. These components are responsible for antilithiatic activity. Therefore, treatment with hydro alcoholic extract of Apium graveolens may prevent calcium oxalate crystal deposition in the kidney by preventing hyperoxaluria induced peroxidative damage to the renal tubular membrane surface (lipid peroxidation), which in turn can prevent calcium oxalate crystal attachment and subsequent development of kidney stones.
| Item Type: | Thesis (Masters) |
|---|---|
| Additional Information: | 261725251 |
| Uncontrolled Keywords: | Anti Urolithiatic Activity, Hydroalcoholic Extract, Apium Graveolens, Ethylene Glycol, Urolithiasis, Wistar Albino Rats |
| Subjects: | PHARMACY > Pharmacology |
| Depositing User: | Ramakrishnan J |
| Date Deposited: | 06 May 2022 06:05 |
| Last Modified: | 06 May 2022 06:05 |
| URI: | http://repository-tnmgrmu.ac.in/id/eprint/19686 |
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