Muhammed Fasil, T (2019) Hepatoprotective Activity of Hemidesmus Indicus in Ethanol Induced Hepatotoxicity. Masters thesis, RVS College of Pharmaceutical Sciences, Coimbatore.
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Abstract
In the present study, the Hemidesmus indicus was selected to evaluate its hepatoprotective effect in preclinical models. The Hemidesmus indicus was evaluated for hepatoprotective activity in Ethanol induced liver toxicity in experimentally induced hepatotoxic rats. Extraction and preliminary phytochemical studies of Hemidesmus indicus revealed the presence of, carbohydrates, steroids, flavonoids, saponins and tannins. Acute oral toxicity study was performed to find out the test dose according to OECD 425 guidelines and HASA was found to be safe at a dose of 2000 mg/kg, b.w. Hepatoprotective activity was studied against Ethanol induced hepatotoxicity, using silymarin (100 mg/kg) body wt as a standard reference. The physical parameters such as wet liver weight and wet liver volume, biochemical parameters (SGPT, SGOT, ALP, BILD, BILT and TP) levels, endogenous enzymes (GSH, SOD, CAT and LPO) level and histopathology of liver were also studied. The maximum effect was seen with 400 mg/kg dose of the extract than the 200 mg/kg in hepatoprotective study. The investigation undertaken was aimed to study hepatoprotective activity of Hemidesmus indicus demonstrated the usefulness and beneficial effects in the treatment of liver disorder induced by Ethanol. The findings of the present study concluded that Hemidesmus indicus witnessed a dose dependent significant hepatoprotective activity. The treatment with Hemidesmus indicus could able to restore the organ (liver) weight and volume at considerable range, which were elevated in hepatotoxic animals, hence proving organ protective activity.The hepatoprotective activity was found to be more significant in high dose (HI-400 mg/kg) compared to low dose (HI-200 mg/kg) in both the animal models. The hepatoprotective potential of Hemidesmus indicus in both the experimental model may be due to the presence of flavonoids, saponins and other polyphenolic compounds which are attributed for the antioxidant activity. The exact mechanism for the hepatoprotective activity of Hemidsmus indicus is still unknown and the protection level was found to be at considerable range. Hence further studies are needed to isolate, characterize the active principles and to find out the exact mechanism responsible for its hepatoprotective activity.
| Item Type: | Thesis (Masters) |
|---|---|
| Additional Information: | 261725657 |
| Uncontrolled Keywords: | Hepatoprotective Activity, Hemidesmus, Ethanol, Hepatotoxicity |
| Subjects: | PHARMACY > Pharmacology |
| Depositing User: | Ramakrishnan J |
| Date Deposited: | 04 May 2022 10:02 |
| Last Modified: | 04 May 2022 10:02 |
| URI: | http://repository-tnmgrmu.ac.in/id/eprint/19654 |
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