Pavithra, S (2019) Design and evaluation of Quinazoline derivatives against breast cancer by dual targeting of HDAC and EGFR through in-silico odeling and screening in-vivo using DMBA induced mammary carcinoma model. Masters thesis, KMCH College Of Pharmacy, Coimbatore.
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Abstract
A new series of quinazoline derivatives have been designed and evaluated in-silico for their activity as dual inhibitor against targets like EGFR and HDAC. The compounds with good efficacy and pharmacokinetics have been synthesized and screened for its efficacy in-vitro. The compound EH01 (N-hydroxy-4-[N'-(7-methoxy-2-phenyl-3,4-dihydroquinazolin-4-yl)hydrazinecarbonyl]benzamide) showed good anticancer activity against MCF-7 cell line. This opens an area on anticancer research by providing a small idea that by combining the pharmacophore of two different targets we can get a newer compound with greater efficacy towards both the targets.
| Item Type: | Thesis (Masters) |
|---|---|
| Additional Information: | 261725812 |
| Uncontrolled Keywords: | Quinazoline derivatives, breast cancer, HDAC and EGFR, in-silico odeling, screening in-vivo, DMBA, carcinoma model |
| Subjects: | PHARMACY > Pharmacology |
| Depositing User: | Ramakrishnan J |
| Date Deposited: | 04 May 2022 06:47 |
| Last Modified: | 04 May 2022 06:47 |
| URI: | http://repository-tnmgrmu.ac.in/id/eprint/19651 |
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