Prithvi, C (2019) Method Development and Validation of RP-HPLC for the Simultaneous Estimation of Niacin and Trans-Resveratrol in Bulk Drug and Dosage Forms by Using Human Plasma. Masters thesis, PSG College of Pharmacy, Coimbatore.
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Abstract
An isocratic novel method has been developed for simultaneous estimation of Niacin and Resveratrol in plasma by RP-HPLC coupled with PDA detector. The proposed method has the ability to separate the components within 10 minutes. This method is simple, rapid and time consuming when compared to other methods so it offers a significant advantage in short run time, economic, rapid extraction, easy sample preparation, good recovery and wide linearity range. All parameters such as precision, accuracy, linearity, robustness, LOD, LOQ and system suitability was validated as per ICH guidelines and the result shows that the method was reliable and acceptable. Therefore, we can conclude that the proposed chromatographic method can be used to analyze samples in routine assay of Niacin and Resveratrol in Bulk drugs and in Plasma.
| Item Type: | Thesis (Masters) |
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| Additional Information: | 261730903 |
| Uncontrolled Keywords: | RP-HPLC, Simultaneous Estimation, Niacin, Trans-Resveratrol, Bulk Drug, Dosage Forms, Human Plasma |
| Subjects: | PHARMACY > Pharmaceutical Analysis |
| Depositing User: | Ramakrishnan J |
| Date Deposited: | 29 Apr 2022 08:54 |
| Last Modified: | 29 Apr 2022 08:54 |
| URI: | http://repository-tnmgrmu.ac.in/id/eprint/19557 |
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