Ezhilarasu Preetham, (2023) Cross-Sectional Study on Correlation between Fasting Lipid Profile and Severity of Chronic Liver Disease in a Tertiary Care Center. Masters thesis, Madras Medical College, Chennai.
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Abstract
INTRODUCTION: Chronic liver Disease (CLD) refers to a slow deterioration of the functions of the liver for more than a period of 6 months which includes detoxification of toxic byproducts produced in the body, maintaining normal coagulation system by production of clotting factors and production of proteins. Cirrhosis comes from the Greek word meaning “tawny” and it was used to refer to a grossly and microarchitecture distorted liver parenchyma which is also dysfunctional . Cirrhosis comes as the fourth leading cause of mortality in Asian males. Chronic Liver Disease is a very commonly seen condition by practitioners through all levels of the healthcare system and Adequate knowledge on its management is key for every doctor. AIMS AND OBJECTIVES: 1. To study the relationship between fasting lipid profile and chronic liver disease. 2. To assess the variation of fasting lipid profile among patients of chronic liver disease according to severity as per child pugh scoring system. Study Centre: Madras Medical College and Rajiv Gandhi Government General Hospital, Chennai. Duration of the study: 6 months. Study Design: Prospective Cross-sectional study. Sample size: 100. Inclusion Criteria: 1. Patients above 18 years of age. 2. Patients giving consent to the study. 3. Patients with chronic liver disease proven by clinical, biochemical and sonological evidence of any etiology. Exclusion Criteria: 1. Patients under 18 years of age. 2. Patient not willing to participate in the study. 3. Patients suffering from co-morbidities that could affect lipid profile such as diabetes, thyroid disease, nephrotic syndrome, cancer, renal failure, history of hyperlipidemia. 4. Patients on drugs that could alter lipid profile like statins and oral contraceptive pills. METHODOLOGY: After obtaining clearance and approval from the institutional ethics committee, and securing informed consent as per the inclusion and exclusion criteria already mentioned, 100 CLD patients getting admitted under institute of internal medicine were studied. Detailed history was recorded - demographics, diet history, intake of drugs, duration of liver disease and alcohol consumption history general clinical examination were done to check for height, weight, blood pressure, pulse rate. Systemic examination was performed focused on abdominal examination. Biochemical tests were performed to assess liver function and coagulation profile in addition random blood sugars and thyroid profile will be performed after 12 hour period of fasting blood sample will be taken to measure the lipid profile in the patients. Patients were subsequently categorised based on child pugh socring system according to the data obtained from proforma. Lipid values of the patients were then compared based on severity of the liver disease as per child pugh scoring system to study the trends of values. CONCLUSION: ● Significant Negative correlation is seen between values of Total cholesterol and severity of Chronic Liver disease. ● Significant Negative correlation is seen between values of LDL cholesterol and severity of Chronic Liver disease. ● Significant Negative correlation is seen between values of HDL cholesterol and severity of Chronic Liver disease. ● Significant Negative correlation is seen between values of Triglycerides and severity of Chronic Liver disease. ● In the future analysis of lipid profile could become an integral part in analysis of any patient with chronic liver disease as is checking their Child pugh score in order to better prognosticate the stage of the disease.
| Item Type: | Thesis (Masters) |
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| Additional Information: | 200120100511 |
| Uncontrolled Keywords: | Cross-Sectional Study on Correlation between Fasting Lipid Profile and Severity of Chronic Liver Disease in a Tertiary Care Center |
| Subjects: | MEDICAL > General Medicine > MEDICAL > General Medicine |
| Depositing User: | Thavamani K |
| Date Deposited: | 17 May 2022 10:43 |
| Last Modified: | 17 Mar 2024 07:56 |
| URI: | http://repository-tnmgrmu.ac.in/id/eprint/19528 |
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