Sowmyasree, K (2019) Development of New RP- HPLC Method for the Estimation of Dolutegravir in the Tablet Dosage Form and Validation of the Method. Masters thesis, Jaya College of Paramedical Sciences, Thiruninravur, Chennai.
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Abstract
The reliability and suitability of the method could be seen from recovery studies. Further there is no interference due to excipients. System suitability parameters were calculated which includes efficiency, resolution and tailing factor. Precision of the methods were studied by making repeated injections of the samples and system precision values were determined. The method was validated for linearity, accuracy, precision, robustness. The method is simple, specific & easy to perform and requires short to analyse the samples. Low limit of Quantification and limit of detection makes this method suitable for Quality control. The method was found to be accurate, precise and robusted. Hence it was concluded that the RP-HPLC method developed was very much suit for routine analysis. Emtricitabine in tablet formulations and future planings use this method for estimation Emtricitabine in clinical trials. FUTURE SCOPE OF WORK: In the above mentioned HPLC method for estimation of Emtricitabine in single tablet dosage form, as the drug Emtricitabine are estimated with hence the present method is faster, can be used for routine analysis of these drugs from tablet formulation.
| Item Type: | Thesis (Masters) |
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| Additional Information: | 261731107 |
| Uncontrolled Keywords: | New RP- HPLC Method, Dolutegravir, Tablet Dosage Form |
| Subjects: | PHARMACY > Pharmaceutical Analysis |
| Depositing User: | Ramakrishnan J |
| Date Deposited: | 28 Apr 2022 10:38 |
| Last Modified: | 28 Apr 2022 10:38 |
| URI: | http://repository-tnmgrmu.ac.in/id/eprint/19527 |
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