Marikomala, P (2023) To Predict Morbidity and Mortality in HIV Infected Individual on Naco Anti Retroviral Therapy Regimen using Modified Veterans Aging Cohort Study Index in a Tertiary Care Hospital. Masters thesis, Madras Medical College, Chennai.
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Abstract
BACKGROUND AND OBJECTIVES: According to a global review of the AIDS epidemic, the World Health Organization (WHO) has reported 31.8 million adult patients as having been infected with the Human Immunodeficiency Virus estimated that the prevalence will be roughly 20.89 lakh in the year 2011, with 0.27% of those instances happening in the adult age group (15-49 years). The results of the EuroSIDA trial indicated that continued antiretroviral therapy (ART) considerably reduced the risk of death and progression to AlDS Studies such as the SMART trial point to potential causes such as inflammation caused by HIV, which is connected with an increased risk of hypercoagulability, and organ system damage caused by ageing. The Veterans Aging Cohort Study Risk Index isa clear scoring system that was designed with the purpose of forecasting mortality rates in HIV patients who have been on treatment for a whole year. METHODS: This study was conducted in ART centre, Rajiv Gandhi Government General Hospital from June 2022 to November 2022. A total 125 case were studied. The Haemoglobin, ALT, AST, serum creatinine, eGFR, FIB-4, HEPATITIS C, CD4 count were included and assessed. Data was entered in MS excel sheet and analysed using SPSS version 21.0. Chi square test and Fisher's exact test was used for finding association. RESULTS: In our study, around 18.4% were in the age group of 18-30 years, 24.8% 31-40 years, 21.6% 41-50 years, 27.2% 51-60 years and 8% more than 60 years and nearly 52.8% were males, and 47.2% were females. mean values of ALT of mean 24.58, and the median ALT levels were 14.50 (Minimum 11.0 to Maximum 27.25). The mean values of platelets were 203.66. The median platelets were 103.22 (145.0 to 258.50). CONCLUSION: The VACS may be a useful indicator of physiologic frailty, indicating the need for more vigilant management or a comprehensive geriatric evaluation. The VACS Index may also assist in alerting healthcare providers and patients when life expectancy is low.
| Item Type: | Thesis (Masters) |
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| Additional Information: | Reg.No.200120100517 |
| Uncontrolled Keywords: | Morbidity, Mortality, HIV Infected Individual, Naco Anti Retroviral Therapy Regimen, Modified Veterans Aging Cohort Study Index, Tertiary Care Hospital. |
| Subjects: | MEDICAL > General Medicine > MEDICAL > General Medicine |
| Depositing User: | Thavamani K |
| Date Deposited: | 17 May 2022 10:36 |
| Last Modified: | 17 Mar 2024 10:54 |
| URI: | http://repository-tnmgrmu.ac.in/id/eprint/19496 |
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