Hemavarthini, A (2023) A Study on Risk Factors, Clinical Profile, Course and Outcome of Acute Kidney Injury in Patients Admitted with Sepsis at a Tertiary Care Centre. Masters thesis, Madras Medical College, Chennai.
Full text not available from this repository.Abstract
INTRODUCTION: Sepsis is the most frequent cause of acute kidney injury (AKI) in critically ill patients in the intensive care unit and is associated with high mortality. Unfortunately, there is no gold-standard method for determining whether a pt is a septic. In a pt with sepsis, the SOFA (sepsis-related organ failure assessment) score and qSOFA score can help in diagnosis and prognosticating a case of sepsis. It is highly imperative to study and better understand the pattern of sepsis-associated AKI in a tertiary care centre for timely intervention and reduction of mortality in patients. AIMS AND OBJECTIVES: Study aimed to assess the risk factors, clinical profile, course, management and outcome of acute kidney injury in patients admitted with sepsis at a tertiary care centre in southern India. MATERIALS AND METHODS: In our study, 100 patients who satisfied the inclusion and exclusion criteria of sepsis –AKI were investigated and prognosticated depending on their SOFA and KDIGO score and followed up throughout their hospital admission for the outcome. RESULTS: In our study population, the mean SOFA score was 10.75 and 57% of population had stage 3 AKI. 46% of population had complete recovery and mortality rate was 15%. The most common etiology was gram negative sepsis followed by diarrhoeal diseases and leptospirosis. A significant positive correlation was noted between Scr, KDIGO staging, GFR, Thrombocytopenia, SOFA score and the mortality of the patients. CONCLUSION: In conclusion, despite improvements in overall sepsis outcomes, SA-AKI is still associated with significant morbidity and mortality. Currently, all SA-AKI management is supportive and focuses on early fluid resuscitation, antibiotic administration and source control.
| Item Type: | Thesis (Masters) |
|---|---|
| Additional Information: | Reg.No.200120100512 |
| Uncontrolled Keywords: | Risk Factors, Clinical Profile, Course, Outcome, Acute Kidney Injury, Sepsis, Tertiary Care Centre. |
| Subjects: | MEDICAL > General Medicine > MEDICAL > General Medicine |
| Depositing User: | Thavamani K |
| Date Deposited: | 17 May 2022 10:35 |
| Last Modified: | 17 Mar 2024 10:15 |
| URI: | http://repository-tnmgrmu.ac.in/id/eprint/19495 |
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