A Case Control study of Neurological Soft Signs in First Episode Psychosis.

Sukumar, S (2007) A Case Control study of Neurological Soft Signs in First Episode Psychosis. Masters thesis, Stanley Medical College, Chennai.


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INTRODUCTION: Abnormal signs in neurology have traditionally been assumed to Be highly informative about the nature and location of disease once the Significance of these signs is understood. There is no reason to assume That this is different in case of psychiatric disorders which are also Revolves and evolves from neuronal system with its unique differences. Classic descriptions of the psychiatric disorders often included Neurological exam findings. Thus, “insane temperament,” “hysteria”, Schizophrenia, mood disorders and obsessive – compulsive disorders Were each thought to have characteristic neurologic exam abnormalities (Sanders & Keshavan, 1998). Neurological signs are traditionally classified into “Hard” and “Soft” signs. Soft signs are defined as minor, non localizable, objective Abnormalities that are thought to reflect damage in connections between Subcortical and cortical areas or between cortical areas. In contrast, hard Neurological signs can be linked to specific areas of neuroanatomical Damage (Barkus et al 2006). Neurological signs are more prominent in Patients with schizophrenia than in healthy controls and in patients with Other psychiatric disorders (Bombin et al 2005). As a whole soft neurological signs have been found to be more Strongly related to the presence of schizophrenia than hard neurological Signs (Bombin et al 2005). The prevalence rates of neurological signs in patients with Schizophrenia ranges from 50 – 65% and 5% in healthy controls (Bombin et al 2005). The prevalence of neurological soft signs in first Episode psychosis patients ranges from 20 – 97% and 5 – 50% in Healthy controls (Dazzan & Murray 2002). The variability in reported prevalence rates are attributed to Differences in the definition of neurological impairment (Bombin et al, 2005) and differences in the scales used for assessment (Dazzan & Murray 2002). This study attempts to study the prevalence of neurological soft Signs in first episode psychosis patients by using the original version of Neurological Evaluation scale ( NES; Buchanan & Heinrichs 1989).

Item Type: Thesis (Masters)
Uncontrolled Keywords: A Case Control ; Neurological Soft Signs ; First Episode Psychosis.
Subjects: MEDICAL > Psychiatry
Depositing User: Subramani R
Date Deposited: 19 Aug 2017 03:05
Last Modified: 19 Aug 2017 03:05
URI: http://repository-tnmgrmu.ac.in/id/eprint/1947

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