Prabhakaran, R (2020) Formulation and Evaluation of Fast Disintegrating Sub Lingual Tablets of Rizatriptan. Masters thesis, J.K.K.Nattraja College of Pharmacy, Kumarapalayam.
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Abstract
The active pharmaceutical ingredient Rizatriptan was subjected to preformulation studies, which encompasses the drug excipients compatibility study and the results obtained with selected excipients showed compatability with Rizatriptan drug. In the present study, fast disintegrating sublingual tablets of Rizatriptan 100mg were prepared by using croscamellose sodium, crospovidone and L-HPC as super disintegrants at the concentration of 3%, 4% and 5% of each and compared the effect of each at different concentrations, and finished the optimum formulation. A total number of 10 formulations were prepared by using different super disintegrants at different concentrations. Among this, formulation F-10 showed maximum effect but formulation F-3 was selected as best formulation because of its wonderful mouth feel which contains drug (5mg), crospovidone 5mg, mannitol (87mg), aspartame(2.5mg) and magnesium stearate(0.5mg). Stability studies were also done for the formulation F-3. Various physico-chemical parameters are tested for this formulation showed good results. From the release study and mathematical models it was concluded that the novel formulation can bypass the first pass metabolism and produced the quicker onset of action.
| Item Type: | Thesis (Masters) |
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| Additional Information: | 261810259 |
| Uncontrolled Keywords: | Formulation, Evaluation, Fast Disintegrating, Sub Lingual Tablets, Rizatriptan |
| Subjects: | PHARMACY > Pharmaceutics |
| Depositing User: | Ramakrishnan J |
| Date Deposited: | 26 Apr 2022 09:05 |
| Last Modified: | 26 Apr 2022 09:05 |
| URI: | http://repository-tnmgrmu.ac.in/id/eprint/19445 |
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