Arunkumar, V (2020) Formulation and In Vitro Evaluation of Gabapentin Controlled Release Tablets Using Natural Polymers. Masters thesis, J.K.K.Nattraja College of Pharmacy, Kumarapalayam.
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Abstract
The main objective of the present study was to develop controlled-release tablets containing 300 mg of gabapentin for epilepsy therapy by using polymers like acacia, agar-agar, guar gum, xanthan gum. The controlled release of the drug delivery system improves the bioavailability and therapeutic efficiency of the drug. In the Preformulation FTIR study was carried out for pure drug (Gabapentin), gabapentin, and excipients. It has not shown any interaction. Construction of the calibration curve was done using 0.1N HCl and phosphate buffer pH 6.8. The formulations F1 o F12 were prepared by the direct compression method.The angle of repose values for formulations range from 25.61±0.03 to 29.57±0.07. Bulk and tapped densities are used for the measurement of the compressibility index. The bulk and tapped values for formulations range from 0.271±0.01 to 0.339±0.06 and 0.317±0.04 to 0.366±0.02 respectively. The carr’s index and Hausner's ratio values for formulations range from 12.29±0.05 to 16.35±0.03 and 1.03±0.05 to 1.25±0.03 respectively. Thus all formulations exhibited good flow characteristics. The prepared controlled-release tablets were evaluated for various parameters like thickness, weight variation, hardness, friability, and drug content uniformity. The thickness of tablets in all formulations was ranged from 5.2±0.007 to 5.3±0.008. The weight variation of tablets in all formulations were ranged from 496±0.04 to 503±0.32.The hardness and friability of all the formulations F1-F12 were found to be 6.4±0.2 to 7.4±0.5 and 0.63 to 0.78 respectively. The drug content of all the formulations were ranging from 98.11±0.14 to 99.19±0.12. In vitro drug release study was carried out for formulations F1 to F12 containing different ratios of natural polymers like acacia, agar-agar, guar gum, and xanthan gum. Among 12 formulations F11 was selected as best formulation based on in vitro drug release. The cumulative percentage drug release of F11 was 99.88% after 12hrs. The kinetic study was carried out for F11 formulation which showed that the drug release follows zero-order kinetics. The stability studies were carried out for F11 formulation at 40oC ± 2oC / 75% RH± 5% for 3months. Data revealed that there was no considerable difference and the product was stable. From the above study, it can be concluded that F11 is the best formulation which has shown better drug release 99.88%. However, further in vivo studies can be carried out to support the results.
| Item Type: | Thesis (Masters) |
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| Additional Information: | 261810251 |
| Uncontrolled Keywords: | Formulation, In Vitro Evaluation, Gabapentin, Release Tablets, Natural Polymers |
| Subjects: | PHARMACY > Pharmaceutics |
| Depositing User: | Ramakrishnan J |
| Date Deposited: | 26 Apr 2022 07:00 |
| Last Modified: | 26 Apr 2022 07:00 |
| URI: | http://repository-tnmgrmu.ac.in/id/eprint/19437 |
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