Self-Double-Emulsifying Drug Delivery System (SDEDDS) of Valsartan for Better Oral Bioavailability

Sundarajan, R (2020) Self-Double-Emulsifying Drug Delivery System (SDEDDS) of Valsartan for Better Oral Bioavailability. Masters thesis, KMCH College Of Pharmacy, Coimbatore.


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Water-in-oil-in-water (w/o/w) double emulsions are potential for enhancing oral bioavailability of drugs with high solubility and low permeability, but their industrial application is limited due to the instability. Herein, we developed a novel formulation, self-double-emulsifying drug delivery systems (SDEDDS) by formulating mixtures of hydrophilic surfactants and water-in-oil (w/o) emulsions, which were easier to be stable through formulations optimization. SDEDDS can spontaneously emulsify to water-in-oil- in-water (w/o/w) double emulsions in the mixed aqueous gastrointestinal environment, with drugs encapsulated in the internal water phase of the double emulsions. We employed SDEDDS to improve the oral absorption of Valsartan, with high solubility and low permeability. The present studies have clearly demonstrated the potential utility of SDEDDS for formulating valsartan with sustained release in vitro.The SDEDDS readily released the lipid phase to form fine water-in-oil-in-water double emulsions, with a sustained release of valsartan.

Item Type: Thesis (Masters)
Additional Information: 261810905
Uncontrolled Keywords: Self-Double-Emulsifying Drug Delivery System (SDEDDS), Valsartan, Better Oral Bioavailability
Subjects: PHARMACY > Pharmaceutics
Depositing User: Ramakrishnan J
Date Deposited: 22 Apr 2022 10:11
Last Modified: 22 Apr 2022 10:11

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