Nithish, K (2020) Formulation, Optimization, and Evaluation of Rivastigmine Tartrate Loaded Solid Lipid Nanoparticle by Microemulsion Technique. Masters thesis, KMCH College Of Pharmacy, Coimbatore.
|
Text
261111420nithish.pdf Download (7MB) | Preview |
Abstract
Solid lipid nanoparticle (SLN) having an attracting importance for drug developer to produce intellectual property through innovations in drug delivery. The objective of present investigation was to develop, optimize and evaluate Rivastigmine tartrate loaded solid lipid nanoparticle (RT SLN) by using central composite design. SLN were prepared by microemulsion method using a systemic approach of design of experiments and evaluated. Various preliminary experiments were performed for selection of suitable excipients. Various lipids and surfactant are selected on the basis of solubility and particle size and thus glyceryl monosterate selected as lipid, and poloxamer 188 as surfactant. Further High speed homogenizer stirring speed and time was optimized HSH is operated at 15000 rpm for 5minutes.Characterization of RT SLN was carried out by infrared spectroscopy (FTIR), scanning electron microscopy (SEM), particle size and zeta potential, differential scanning calorimetry (DSC), entrapment efficiency, in vitro drug release and kinetics. Particle size of optimized formulation is 152.4 nm and PDI value 0.198 indicates mono dispersion. Optimized formulation with zeta potential -31.4 mV was found to be stable. Entrapment efficiency of optimized formulation is 76.1%. This condition has shown an improved response values in comparison with the previously optimized formulation. SEM photographs of RT SLN indicate particles have uniform loose aggregates, spherical in shape with a smooth surface and they are uniformly distributed. On comparison of in vitro drug release studies of RT solution and RT SLN shows that RT SLN has higher release 87.74% at 12 hrs compared to RT solution RT Solution 61.59%. From the obtained results it was concluded that the Rivastigmine Tartrate SLNs can be employed for controlled delivery of drug in the treatment of Alzheimer’s disease.
| Item Type: | Thesis (Masters) |
|---|---|
| Additional Information: | 261810902 |
| Uncontrolled Keywords: | Formulation, Optimization, Evaluation, Rivastigmine Tartrate, Solid Lipid Nanoparticle, Microemulsion Technique |
| Subjects: | PHARMACY > Pharmaceutics |
| Depositing User: | Ramakrishnan J |
| Date Deposited: | 21 Apr 2022 09:23 |
| Last Modified: | 21 Apr 2022 09:23 |
| URI: | http://repository-tnmgrmu.ac.in/id/eprint/19358 |
Actions (login required)
 |
View Item |
