Iswariya Lakshmi, S S (2022) A Comparative study of Efficacy of Ovulation Induction Drugs alone Versus Ovulation Induction Drugs and Gonadotropins in Infertility. Masters thesis, Madras Medical College, Chennai.
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Abstract
BACKGROUND: Infertility is defined as one year of regular unprotected intercourse without conception. Infertility affects approximately 10-15% of couples. Fertility in women peaks between the ages of 20 and 24 and then declines progressively. The main causes of infertility includes ovulatory dysfunction, tubal and peritoneal pathology, male factors and unexplained infertility. Ovulation induction refers to the therapeutic restoration of the release of one egg per cycle in the women who either has not been ovulating regularly or has not been ovulating at all. AIMS AND OBJECTIVES: Apart from comparing the efficacy of ovulation induction drugs alone versus ovulation induction drugs and gonadotropins, to compare the number and size of dominant follicle in both the groups, to compare mean diameter of the dominant follicle and Endometrial thickness achieved in both the groups, to compare the ovulation rate and pregnancy rate in both the groups. MATERIALS AND METHODS: 200 women were included in the study who had attended Fertility Research centre at Institute of Obstetrics and Gynaecology and Government Hospital for Women and Children, Egmore and Institute of Social Obstetrics and Government Kasturba Gandhi Hospital for Women and Children, Triplicane from September 2020 to September 2021. RESULTS: Monofollicular rate, mean diameter of Dominant follicle, Endometrial thickness were higher in Letrozole and gonadotropins. Ovulation and pregnancy rate were higher in Letrozole and Gonadotropins group compared to other groups. Multifolliculogenesis was higher in clomiphene plus gonadotropin group. CONCLUSION: The current study concluded that the combination of letrozole plus gonadotropins compared to other groups, seems to be more efficacious for inducing ovulation, in the development of adequate mean diameter of dominant follicle with appropriate ET followed by high rate of monofolliculogenesis. It also reduces the OHSS and multiple pregnancy. Hence, it is the preferred treatment modality for superovulation in unexplained infertility.
| Item Type: | Thesis (Masters) |
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| Additional Information: | 221916864 |
| Uncontrolled Keywords: | Infertility, Ovulation Induction, Letrozole, monofolliculogenesis. |
| Subjects: | MEDICAL > Obstetrics and Gynaecology > MEDICAL > Obstetrics and Gynaecology |
| Depositing User: | Subramani R |
| Date Deposited: | 17 Apr 2022 08:44 |
| Last Modified: | 27 Nov 2023 15:47 |
| URI: | http://repository-tnmgrmu.ac.in/id/eprint/19331 |
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