Revathy, M (2022) Comparative Study of Efficacy and Safety of Intravenous Iron Sucrose Versus Ferric Carboxy Maltose in the Treatment of Postpartum Iron Deficiency Anaemia. Masters thesis, ESIC Medical College and PGIMSR, Chennai.
|
Text
220649522revathy.pdf Download (2MB) | Preview |
Abstract
BACKGROUND: Childbirth should be a joyous event. However, unforeseen medical problems such as postpartum haemorrhage or postpartum anaemia can develop and make this time very difficult. Postpartum anaemia is observed in up to 27% of postpartum women. It is a major contributable factor and indirect cause of maternal death. Iron deficiency is the commonest treatable cause of postpartum anaemia. Parental iron therapy with Ferric carboxy maltose (FCM) which is the third generation compound results in faster and higher replenishment of iron stores with correction of Hb levels and better patient compliance compared to other parenteral compounds and oral drugs. AIM OF THE STUDY: To compare the efficacy and safety of intravenous ferric carboxy maltose versus intravenous iron sucrose in the treatment of postpartum iron deficiency anaemia OBJECTIVES: 1. To compare the efficacy of intravenous ferric carboxy maltose versus intravenous iron sucrose in postpartum anaemia correction. 2. To compare the raise in haemoglobin and other indices such as serum ferritin, MCV, PCV, MCHC and MCH between the two groups. 3. To compare the adverse reactions between the two groups. MATERIALS AND METHODS: This was a prospective, randomized comparative study conducted between November 2019 to April 2021 in Department of Obstetrics & Gynaecology, ESIC Medical College & PGIMSR, K.K. Nagar, Chennai. Postpartum women with Hb – 7 to 9 g/dl detected 24 hours after delivery were included. Total Sample size obtained was 63. Iron Sucrose (IS) group included 21 postpartum women and Ferric Carboxy Maltose (FCM) group included 42 postpartum women in the ratio of 1:2. Randomisation was done by computerized random number generation method. Postpartum women who fulfills the inclusion criteria were included in the study after obtaining their informed consent. The demographic profile and baseline clinical data such as age, parity, SES, educational status, presence of antenatal anaemia and mode of delivery was compared between both the groups. Iron requirement was calculated by GANZONI FORMULA and transfused intravenously. No test dose required in both the drugs. Pretransfusion vitals documented and patients were monitored for any adverse reactions such as pain, itching, rash, headache, dizziness, nausea and vomiting post transfusion. Baseline values of Haemoglobin, ferritin, MCV, MCHC, PCV and MCH were noted and repeated at the end of 4 weeks and 12 weeks of therapy. The observed values were compared and analysed. RESULT: The improvement in Haemoglobin, ferritin, MCV, MCHC, PCV and MCH was better and more rapid with ferric carboxy maltose than iron sucrose and it was found to be statistically significant. Also, the use of high single dose of FCM reduced the number of infusions, enabling the possibility of cost reductions compared to multiple administrations. FCM lacks dextran and less immunogenic, so adverse reactions are also low. The occurrence of adverse reactions in FCM group was not significant compared to iron sucrose (p=0.54). The overall satisfaction reported by the postpartum patients was better as they received the drug with minimum hospital stay in a single dose. CONCLUSION: The ability to deliver a high dose of iron within a short time, with single prick and less adverse effects make FCM suitable for patients requiring quicker restoration of iron stores in postpartum period and can be recommended for anaemic postpartum women.
| Item Type: | Thesis (Masters) |
|---|---|
| Additional Information: | 221916554 |
| Uncontrolled Keywords: | Ferric carboxy maltose, Iron sucrose, Postpartum anaemia, Haemoglobin, Serum Ferritin, Iron deficiency. |
| Subjects: | MEDICAL > Obstetrics and Gynaecology > MEDICAL > Obstetrics and Gynaecology |
| Depositing User: | Subramani R |
| Date Deposited: | 14 Apr 2022 05:01 |
| Last Modified: | 20 Nov 2023 11:45 |
| URI: | http://repository-tnmgrmu.ac.in/id/eprint/19265 |
Actions (login required)
 |
View Item |
